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2010 1
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Page 1
KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
Li M, Ma Y, Zhong Y, Liu Q, Chen C, Qiang L, Wang X. Li M, et al. J Immunother Cancer. 2020 Oct;8(2):e000293. doi: 10.1136/jitc-2019-000293. J Immunother Cancer. 2020. PMID: 33037113 Free PMC article.
BACKGROUND: kalirin RhoGEF kinase (KALRN) is mutated in a wide range of cancers. Nevertheless, the association between KALRN mutations and the pathogenesis of cancer remains unexplored. ...Also, programmed cell death 1 ligand (PD-L1) expression was mar …
BACKGROUND: kalirin RhoGEF kinase (KALRN) is mutated in a wide range of cancers. Nevertheless, the association between KALR …
Metabolism-associated molecular classification of cervical cancer.
Zhao M, Zhang X, Huan Q, Dong M. Zhao M, et al. BMC Womens Health. 2023 Oct 26;23(1):555. doi: 10.1186/s12905-023-02712-6. BMC Womens Health. 2023. PMID: 37884919 Free PMC article.
RESULTS: Our results identified 3620 metabolism-related genes in CESC, 2493 of which contained related mutations. The co-occurrence of CUBN, KALRN, and HERC1 was related to the prognosis of CESC. The fraction of genome altered (FGA) closely correlated with overall survival …
RESULTS: Our results identified 3620 metabolism-related genes in CESC, 2493 of which contained related mutations. The co-occurrence of CUBN, …
Dbl family RhoGEFs in cancer: different roles and targeting strategies.
Chen XY, Cheng AY, Wang ZY, Jin JM, Lin JY, Wang B, Guan YY, Zhang H, Jiang YX, Luan X, Zhang LJ. Chen XY, et al. Biochem Pharmacol. 2024 May;223:116141. doi: 10.1016/j.bcp.2024.116141. Epub 2024 Mar 16. Biochem Pharmacol. 2024. PMID: 38499108 Review.
More and more emphasis has been paid to the Dbl family members for their abnormally high expression in various cancers and their correlation to poor prognosis. In this review, the common and distinctive structures of Dbl family members are discussed, and their roles in …
More and more emphasis has been paid to the Dbl family members for their abnormally high expression in various cancers and their corr …
Weighted Correlation Network Analysis of Cancer Stem Cell-Related Prognostic Biomarkers in Esophageal Squamous Cell Carcinoma.
Zhao M, Jin X, Chen Z, Zhang H, Zhan C, Wang H, Wang Q. Zhao M, et al. Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221117003. doi: 10.1177/15330338221117003. Technol Cancer Res Treat. 2022. PMID: 35899307 Free PMC article.
Background: The role of cancer stem cells in esophageal squamous cell carcinoma (ESCC) remains unclear. ...In vitro assays showed that CST1, CILP, PITX2, F2RL2, and RIOX1 were pro-proliferated, which were opposite for DDP4 and ZFHX4. In addition, SMARCA4, NOTCH3, DNAH5, an …
Background: The role of cancer stem cells in esophageal squamous cell carcinoma (ESCC) remains unclear. ...In vitro assays showed tha …
Extracellular Vesicles May Predict Response to Radioembolization and Sorafenib Treatment in Advanced Hepatocellular Carcinoma: An Exploratory Analysis from the SORAMIC Trial.
Shuen TWH, Alunni-Fabbroni M, Öcal E, Malfertheiner P, Wildgruber M, Schinner R, Pech M, Benckert J, Sangro B, Kuhl C, Gasbarrini A, Chow PKH, Toh HC, Ricke J. Shuen TWH, et al. Clin Cancer Res. 2022 Sep 1;28(17):3890-3901. doi: 10.1158/1078-0432.CCR-22-0569. Clin Cancer Res. 2022. PMID: 35763041 Free PMC article. Clinical Trial.
High EV-GPX3/ACTR3 and low EV-ARHGAP1 were identified as candidate biomarkers at baseline from the 13 responders to SIRT+sorafenib with statistically significant AUC = 1 for all and bootstrap P values 2.23 10-5, 2.22 10-5, and 2.23 10-5, respectively. These patients showed reduce …
High EV-GPX3/ACTR3 and low EV-ARHGAP1 were identified as candidate biomarkers at baseline from the 13 responders to SIRT+sorafenib with stat …
Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma.
Afanasyeva EA, Gartlgruber M, Ryl T, Decaesteker B, Denecker G, Mönke G, Toprak UH, Florez A, Torkov A, Dreidax D, Herrmann C, Okonechnikov K, Ek S, Sharma AK, Sagulenko V, Speleman F, Henrich KO, Westermann F. Afanasyeva EA, et al. Life Sci Alliance. 2021 Mar 3;4(5):e201900332. doi: 10.26508/lsa.201900332. Print 2021 May. Life Sci Alliance. 2021. PMID: 33658318 Free PMC article.
Altogether, these data support the introduction of NUC inhibitors into cancer treatment research....
Altogether, these data support the introduction of NUC inhibitors into cancer treatment research....
A newly identified small molecular compound acts as a protein kinase inhibitor to suppress metastasis of colorectal cancer.
Qi L, Zhang Y, Song F, Han Y, Ding Y. Qi L, et al. Bioorg Chem. 2021 Feb;107:104625. doi: 10.1016/j.bioorg.2021.104625. Epub 2021 Jan 7. Bioorg Chem. 2021. PMID: 33454506
BACKGROUND: Targeted therapy has demonstrated high efficacy in the treatment of advanced cancer, and protein kinase inhibitors are a major focus of that therapy; therefore, our study aimed to identify a new protein kinase inhibitor that could be used in the treatment of ad …
BACKGROUND: Targeted therapy has demonstrated high efficacy in the treatment of advanced cancer, and protein kinase inhibitors are a …
Identifying specific miRNAs and associated mRNAs in CD44 and CD90 cancer stem cell subtypes in gastric cancer cell line SNU-5.
Liu HQ, Shu X, Ma Q, Wang R, Huang MY, Gao X, Liu YN. Liu HQ, et al. Int J Clin Exp Pathol. 2020 Jun 1;13(6):1313-1323. eCollection 2020. Int J Clin Exp Pathol. 2020. PMID: 32661467 Free PMC article.
Cancer stem cells (CSCs) are capable of generating multiple types of cells and play a vital role in promoting gastric cancer (GC) progression. ...In CD44+ CSCs, we observed hsa-miR-15b-5p was up-regulated and its target genes AMOT, USP31, KALRN, EPB41L4B, ATP …
Cancer stem cells (CSCs) are capable of generating multiple types of cells and play a vital role in promoting gastric cancer ( …
G908R NOD2 variant in a family with sarcoidosis.
Besnard V, Calender A, Bouvry D, Pacheco Y, Chapelon-Abric C, Jeny F, Nunes H, Planès C, Valeyre D. Besnard V, et al. Respir Res. 2018 Mar 20;19(1):44. doi: 10.1186/s12931-018-0748-5. Respir Res. 2018. PMID: 29554915 Free PMC article.
This variant is associated with the presence of three additional SNPs for the IL17RA, KALRN and EPHA2 genes, which discriminate patients expressing the disease from others. ...CONCLUSIONS: Combination of polymorphisms in the NOD2, IL17RA, EPHA2 and KALRN genes could …
This variant is associated with the presence of three additional SNPs for the IL17RA, KALRN and EPHA2 genes, which discriminate patie …
A Protein Microarray-Based Investigation of Cerebrospinal Fluid Reveals Distinct Autoantibody Signature in Low and High-Grade Gliomas.
Gahoi N, Syed P, Choudhary S, Epari S, Moiyadi A, Varma SG, Gandhi MN, Srivastava S. Gahoi N, et al. Front Oncol. 2020 Dec 22;10:543947. doi: 10.3389/fonc.2020.543947. eCollection 2020. Front Oncol. 2020. PMID: 33415070 Free PMC article.
Proteins showing significant antigenic response were cross-verified. Proteins NOL4 (a cancer-testis antigen) and KALRN showed an antigenic response in the CSF of GBM patients, whereas, UTP4 and CCDC28A showed an antigenic response in low grade gliomas when compared …
Proteins showing significant antigenic response were cross-verified. Proteins NOL4 (a cancer-testis antigen) and KALRN showed …
17 results