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1986 1
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2002 5
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2004 4
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149 results

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Page 1
Did you mean del cancer (63,262 results)?
Acquired Resistance to KRAS(G12C) Inhibition in Cancer.
Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, Zhu VW, Johnson ML, Heist RS, Patil T, Riely GJ, Jacobson JO, Yang X, Persky NS, Root DE, Lowder KE, Feng H, Zhang SS, Haigis KM, Hung YP, Sholl LM, Wolpin BM, Wiese J, Christiansen J, Lee J, Schrock AB, Lim LP, Garg K, Li M, Engstrom LD, Waters L, Lawson JD, Olson P, Lito P, Ou SI, Christensen JG, Jänne PA, Aguirre AJ. Awad MM, et al. N Engl J Med. 2021 Jun 24;384(25):2382-2393. doi: 10.1056/NEJMoa2105281. N Engl J Med. 2021. PMID: 34161704 Free PMC article.
BACKGROUND: Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS glycine-to-cysteine amino acid substitutions at codon 12 (KRAS(G12C)). ...RESULTS: A total of 38 patients were included in this study: 27 with …
BACKGROUND: Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring KRAS gl …
Criteria for the translation of radiomics into clinically useful tests.
Huang EP, O'Connor JPB, McShane LM, Giger ML, Lambin P, Kinahan PE, Siegel EL, Shankar LK. Huang EP, et al. Nat Rev Clin Oncol. 2023 Feb;20(2):69-82. doi: 10.1038/s41571-022-00707-0. Epub 2022 Nov 28. Nat Rev Clin Oncol. 2023. PMID: 36443594 Free PMC article. Review.
Homologous and Heterologous Covid-19 Booster Vaccinations.
Atmar RL, Lyke KE, Deming ME, Jackson LA, Branche AR, El Sahly HM, Rostad CA, Martin JM, Johnston C, Rupp RE, Mulligan MJ, Brady RC, Frenck RW Jr, Bäcker M, Kottkamp AC, Babu TM, Rajakumar K, Edupuganti S, Dobrzynski D, Coler RN, Posavad CM, Archer JI, Crandon S, Nayak SU, Szydlo D, Zemanek JA, Dominguez Islas CP, Brown ER, Suthar MS, McElrath MJ, McDermott AB, O'Connell SE, Montefiori DC, Eaton A, Neuzil KM, Stephens DS, Roberts PC, Beigel JH; DMID 21-0012 Study Group. Atmar RL, et al. N Engl J Med. 2022 Mar 17;386(11):1046-1057. doi: 10.1056/NEJMoa2116414. Epub 2022 Jan 26. N Engl J Med. 2022. PMID: 35081293 Free PMC article. Clinical Trial.
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Corrales L, Glickman LH, McWhirter SM, Kanne DB, Sivick KE, Katibah GE, Woo SR, Lemmens E, Banda T, Leong JJ, Metchette K, Dubensky TW Jr, Gajewski TF. Corrales L, et al. Cell Rep. 2015 May 19;11(7):1018-30. doi: 10.1016/j.celrep.2015.04.031. Epub 2015 May 7. Cell Rep. 2015. PMID: 25959818 Free PMC article.
IT injection of STING agonists induced profound regression of established tumors in mice and generated substantial systemic immune responses capable of rejecting distant metastases and providing long-lived immunologic memory. Synthetic CDNs have high translational potential as a …
IT injection of STING agonists induced profound regression of established tumors in mice and generated substantial systemic immune responses …
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B. Hillig RC, et al. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25. Proc Natl Acad Sci U S A. 2019. PMID: 30683722 Free PMC article.
Since the late 1980s, mutations in the RAS genes have been recognized as major oncogenes with a high occurrence rate in human cancers. Such mutations reduce the ability of the small GTPase RAS to hydrolyze GTP, keeping this molecular switch in a constitutively active GTP-b …
Since the late 1980s, mutations in the RAS genes have been recognized as major oncogenes with a high occurrence rate in human cancers …
Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia.
Liu W, Wu Z, Yu Y, Qiao C, Zhu H, Hong M, Zhu Y, Qian S, Chen S, Wu D, Li J, Jin H. Liu W, et al. Oxid Med Cell Longev. 2022 Jan 30;2022:5885342. doi: 10.1155/2022/5885342. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35140839 Free PMC article.
In this study, we demonstrated that KEL promoted cell proliferation and the downregulation of KEL reversed drug resistance in AEL cells to JQ1. ...Additionally, GATA1 and TAL1 as cotranscription factors (TFs) modulated the expression of KEL. Maintaining cell …
In this study, we demonstrated that KEL promoted cell proliferation and the downregulation of KEL reversed drug resistance in …
Tele-Neuro-Ophthalmology During the Age of COVID-19.
Lai KE, Ko MW, Rucker JC, Odel JG, Sun LD, Winges KM, Ghosh A, Bindiganavile SH, Bhat N, Wendt SP, Scharf JM, Dinkin MJ, Rasool N, Galetta SL, Lee AG. Lai KE, et al. J Neuroophthalmol. 2020 Sep;40(3):292-304. doi: 10.1097/WNO.0000000000001024. J Neuroophthalmol. 2020. PMID: 32604249 Free PMC article. Review.
Cancer of the gastric cardia.
McColl KE. McColl KE. Best Pract Res Clin Gastroenterol. 2006;20(4):687-96. doi: 10.1016/j.bpg.2006.03.005. Best Pract Res Clin Gastroenterol. 2006. PMID: 16997153 Review.
Current evidence indicates that cardia cancers are of at least two distinct and disparate aetiologies. One type resembles cancer of the more distal stomach (Type A), being a consequence of atrophic gastritis due to Helicobacter pylori infection or more rarely autoim …
Current evidence indicates that cardia cancers are of at least two distinct and disparate aetiologies. One type resembles cancer …
Identification of unique rectal cancer-specific subtypes.
Kisakol B, Matveeva A, Salvucci M, Kel A, McDonough E, Ginty F, Longley DB, Prehn JHM. Kisakol B, et al. Br J Cancer. 2024 May;130(11):1809-1818. doi: 10.1038/s41416-024-02656-0. Epub 2024 Mar 26. Br J Cancer. 2024. PMID: 38532103 Free PMC article.
METHODS: We collected mRNA expression profiles for rectal and colon cancer samples (n = 2121). We observed that (i) Consensus Molecular Subtyping (CMS) had a different prognosis in treatment-naive rectal vs. colon cancers, and (ii) that neoadjuvant chemoradiotherapy …
METHODS: We collected mRNA expression profiles for rectal and colon cancer samples (n = 2121). We observed that (i) Consensus Molecul …
Topography of cancer-associated immune cells in human solid tumors.
Kather JN, Suarez-Carmona M, Charoentong P, Weis CA, Hirsch D, Bankhead P, Horning M, Ferber D, Kel I, Herpel E, Schott S, Zörnig I, Utikal J, Marx A, Gaiser T, Brenner H, Chang-Claude J, Hoffmeister M, Jäger D, Halama N. Kather JN, et al. Elife. 2018 Sep 4;7:e36967. doi: 10.7554/eLife.36967. Elife. 2018. PMID: 30179157 Free PMC article.
Yet, there is no comprehensive understanding of spatial immune infiltration patterns ('topography') across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue …
Yet, there is no comprehensive understanding of spatial immune infiltration patterns ('topography') across cancer entities and across …
149 results