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Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.
Pan R, Cai W, Sun J, Yu C, Li P, Zheng M. Pan R, et al. J Cell Physiol. 2020 Feb;235(2):1576-1587. doi: 10.1002/jcp.29076. Epub 2019 Jul 16. J Cell Physiol. 2020. PMID: 31313286
However, to date, the role of KHSRP in colorectal cancer (CRC) progression has not been reported. ...We found that KHSRP decreased ERRFI1 mRNA expression indirectly. By screening KHSRP-regulated miRNAs, we further found that miR-501-5p directly combine …
However, to date, the role of KHSRP in colorectal cancer (CRC) progression has not been reported. ...We found that KHSRP
LncRNA LINC01305 promotes cervical cancer progression through KHSRP and exosome-mediated transfer.
Huang X, Liu X, Du B, Liu X, Xue M, Yan Q, Wang X, Wang Q. Huang X, et al. Aging (Albany NY). 2021 Feb 26;13(15):19230-19242. doi: 10.18632/aging.202565. Epub 2021 Feb 26. Aging (Albany NY). 2021. PMID: 33638945 Free PMC article.
Cervical cancer (CC) is one of the deadliest female malignancies worldwide. Long non-coding RNAs (lncRNAs) are essential regulators for cancer progression. This study aimed to elucidate the role of lncRNA LINC01305 in the progression of CC. ...
Cervical cancer (CC) is one of the deadliest female malignancies worldwide. Long non-coding RNAs (lncRNAs) are essential regulators f …
Enhancer RNA promotes resistance to radiotherapy in bone-metastatic prostate cancer by m(6)A modification.
Zhao Y, Wen S, Li H, Pan CW, Wei Y, Huang T, Li Z, Yang Y, Fan S, Zhang Y. Zhao Y, et al. Theranostics. 2023 Jan 1;13(2):596-610. doi: 10.7150/thno.78687. eCollection 2023. Theranostics. 2023. PMID: 36632223 Free PMC article.
Rationale: Prostate cancer metastasizes to the bone with the highest frequency and exhibits high resistance to (177)Lu-prostate-specific membrane antigen (PSMA) radioligand therapy. ...Depletion of the MLXIPe/KHSRP/PSMD9 regulatory complex inhibited tumor growth and …
Rationale: Prostate cancer metastasizes to the bone with the highest frequency and exhibits high resistance to (177)Lu-prostate-speci …
KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer.
Taniuchi K, Ogasawara M. Taniuchi K, et al. Oncotarget. 2020 Jan 14;11(2):131-147. doi: 10.18632/oncotarget.27413. eCollection 2020 Jan 14. Oncotarget. 2020. PMID: 32010427 Free PMC article.
The present study reports that KHSRP promotes invasiveness and metastasis of pancreatic cancer cells. KHSRP was localized in the nucleus and cell protrusions of pancreatic cancer cell lines. ...
The present study reports that KHSRP promotes invasiveness and metastasis of pancreatic cancer cells. KHSRP was localiz …
Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis.
Chen L, Zhao T. Chen L, et al. Cancer Biother Radiopharm. 2021 Jun;36(5):412-424. doi: 10.1089/cbr.2020.3745. Epub 2020 Jul 14. Cancer Biother Radiopharm. 2021. PMID: 32673063
Background: The objective of this study was to identify key molecules that included long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs involved in esophageal cancer with KH-type splicing regulatory protein (KHSRP) knockdown. ...Also, the correlation analys …
Background: The objective of this study was to identify key molecules that included long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and m …
RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.
Yan M, Sun L, Li J, Yu H, Lin H, Yu T, Zhao F, Zhu M, Liu L, Geng Q, Kong H, Pan H, Yao M. Yan M, et al. J Exp Clin Cancer Res. 2019 Nov 27;38(1):478. doi: 10.1186/s13046-019-1479-2. J Exp Clin Cancer Res. 2019. PMID: 31775888 Free PMC article.
BACKGROUND: KH-type splicing regulatory protein (KHSRP) plays an important role in cancer invasion, but the relevant mechanism is not well known. ...In NSCLC cell lines, knockdown of KHSRP significantly reduced lung cancer cell proliferation, migration …
BACKGROUND: KH-type splicing regulatory protein (KHSRP) plays an important role in cancer invasion, but the relevant mechanism …
Regulation of the MIR155 host gene in physiological and pathological processes.
Elton TS, Selemon H, Elton SM, Parinandi NL. Elton TS, et al. Gene. 2013 Dec 10;532(1):1-12. doi: 10.1016/j.gene.2012.12.009. Epub 2012 Dec 14. Gene. 2013. PMID: 23246696 Review.
MiR-155-5p is one of the best characterized miRNAs and recent data indicate that miR-155-5p plays a critical role in various physiological and pathological processes such as hematopoietic lineage differentiation, immunity, inflammation, viral infections, cancer, cardiovasc …
MiR-155-5p is one of the best characterized miRNAs and recent data indicate that miR-155-5p plays a critical role in various physiological a …
KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation.
Xu J, Wang D, Ma H, Zhai X, Huo Y, Ren Y, Li W, Chang L, Lu D, Guo Y, Si Y, Gao Y, Wang X, Ma Y, Wang F, Yu J. Xu J, et al. Blood Sci. 2022 Jul 1;4(3):103-115. doi: 10.1097/BS9.0000000000000122. eCollection 2022 Jul. Blood Sci. 2022. PMID: 36518592 Free PMC article.
In this study, we revealed that KHSRP regulates monocytic differentiation by regulating gene transcription and RNA splicing. ...Of note, KHSRP had co-regulatory effects at both the transcriptional and posttranscriptional levels on MOGOH and ADARB1. ...
In this study, we revealed that KHSRP regulates monocytic differentiation by regulating gene transcription and RNA splicing. ...Of no …
SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis.
Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, Wang Y, Xu M, Jiang B, Yu J. Yuan H, et al. Mol Cancer. 2017 Oct 11;16(1):157. doi: 10.1186/s12943-017-0724-6. Mol Cancer. 2017. PMID: 29020972 Free PMC article.
METHODS: The in vivo SUMOylation assay using the Ni(2+)-NTA affinity pulldown or immunoprecipitation (IP) and the in vitro E.coli-based SUMOylation assay were used to analyze SUMOylation of KHSRP. Nuclear/Cytosol fractionation assay and immunofluorescent staining were used …
METHODS: The in vivo SUMOylation assay using the Ni(2+)-NTA affinity pulldown or immunoprecipitation (IP) and the in vitro E.coli-based SUMO …
KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer.
Tong L, Luo Y, Wei T, Guo L, Wang H, Zhu W, Zhang J. Tong L, et al. Mol Cell Biochem. 2016 Nov;422(1-2):61-74. doi: 10.1007/s11010-016-2806-y. Epub 2016 Sep 19. Mol Cell Biochem. 2016. PMID: 27644194
KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein that has a role in tumorigenesis of small cell lung cancer. The KHSRP protein level was shown to be significantly increased in small cell lung cancer (SCLC) tumor tiss …
KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein that has a role in tumorigenesis of small cell l …
73 results