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17 results

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Page 1
KIFC3 Regulates the progression and metastasis of gastric cancer via Notch1 pathway.
He Y, He P, Lu S, Dong W. He Y, et al. Dig Liver Dis. 2023 Sep;55(9):1270-1279. doi: 10.1016/j.dld.2023.02.014. Epub 2023 Mar 6. Dig Liver Dis. 2023. PMID: 36890049
INTRODUCTION: KIFC3 is a member of the kinesin family which has shown great promise in cancer therapy recently. ...The proliferation and metastasis ability of GC cells were promoted by KIFC3 overexpression while inhibited by KIFC3 knockdown in vitro an …
INTRODUCTION: KIFC3 is a member of the kinesin family which has shown great promise in cancer therapy recently. ...The prolife …
KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway.
Liao H, Zhang L, Lu S, Li W, Dong W. Liao H, et al. Front Genet. 2022 Jun 22;13:848926. doi: 10.3389/fgene.2022.848926. eCollection 2022. Front Genet. 2022. PMID: 35812733 Free PMC article.
KIFC3 has been identified as a docetaxel resistance gene in breast cancer cells, however, the role of KIFC3 and its potential mechanism in colorectal cancer (CRC) remains elusive. ...KIFC3 overexpression promoted the G1/S phase transition. KI …
KIFC3 has been identified as a docetaxel resistance gene in breast cancer cells, however, the role of KIFC3 and its pot …
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.
Lu S, Liu Y, Tian S, He Y, Dong W. Lu S, et al. Exp Cell Res. 2023 May 1;426(1):113564. doi: 10.1016/j.yexcr.2023.113564. Epub 2023 Mar 21. Exp Cell Res. 2023. PMID: 36948354
KIFC3 is involved in cell division and cancers. However, the role of KIFC3 in HCC has yet to be elucidated. ...RESULT: We found that the expression of KIFC3 was upregulated in HCC, and high KIFC3 expression was related to poor overall survival. …
KIFC3 is involved in cell division and cancers. However, the role of KIFC3 in HCC has yet to be elucidated. ...RESULT: …
KIFC3 promotes proliferation, migration and invasion of esophageal squamous cell carcinoma cells by activating EMT and beta-catenin signaling.
Hao WW, Xu F. Hao WW, et al. World J Gastrointest Oncol. 2022 Jul 15;14(7):1239-1251. doi: 10.4251/wjgo.v14.i7.1239. World J Gastrointest Oncol. 2022. PMID: 36051093 Free PMC article.
However, the role of KIFC3 in ESCC is still unknown. AIM: To evaluate the role of KIFC3 in ESCC and the underlying mechanisms. ...In addition, cell cycle analysis showed that KIFC3 overexpression promoted cell cycle progression. KIFC3 knockdown suppres …
However, the role of KIFC3 in ESCC is still unknown. AIM: To evaluate the role of KIFC3 in ESCC and the underlying mechanisms. …
The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly.
Hata S, Pastor Peidro A, Panic M, Liu P, Atorino E, Funaya C, Jäkle U, Pereira G, Schiebel E. Hata S, et al. Nat Cell Biol. 2019 Sep;21(9):1138-1151. doi: 10.1038/s41556-019-0382-6. Epub 2019 Sep 2. Nat Cell Biol. 2019. PMID: 31481795
KIFC3 forms a homotetramer that pulls the two centrosomes together via a specific microtubule network. ...KIFC3 is eventually inactivated by NEver in mitosis-related Kinase 2 (NEK2) to enable EG5-driven bipolar spindle assembly. ...
KIFC3 forms a homotetramer that pulls the two centrosomes together via a specific microtubule network. ...KIFC3 is eventually …
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer.
Li TF, Zeng HJ, Shan Z, Ye RY, Cheang TY, Zhang YJ, Lu SH, Zhang Q, Shao N, Lin Y. Li TF, et al. Cancer Cell Int. 2020 Apr 15;20:123. doi: 10.1186/s12935-020-01191-1. eCollection 2020. Cancer Cell Int. 2020. PMID: 32322170 Free PMC article.
RESULTS: A total of 20 differentially expressed KIFs were identified between breast cancer and normal tissue with 4 (KIF17, KIF26A, KIF7, KIFC3) downregulated and 16 (KIF10, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF24, KIF26B, KIF2C, KIF …
RESULTS: A total of 20 differentially expressed KIFs were identified between breast cancer and normal tissue with 4 (KIF17, KIF26A, K …
Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.
Tan MH, De S, Bebek G, Orloff MS, Wesolowski R, Downs-Kelly E, Budd GT, Stark GR, Eng C. Tan MH, et al. Breast Cancer Res Treat. 2012 Feb;131(3):849-58. doi: 10.1007/s10549-011-1500-8. Epub 2011 Apr 9. Breast Cancer Res Treat. 2012. PMID: 21479552 Free PMC article.
Breast cancer is a genetically heterogenous disease with subtypes differing in prognosis and chemosensitivity. ...KIF12 is the most overexpressed KIF gene in post-chemotherapy taxane-resistant residual breast cancers (2.8-fold-change). Functional studies established …
Breast cancer is a genetically heterogenous disease with subtypes differing in prognosis and chemosensitivity. ...KIF12 is the most o …
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.
Shokrollahi M, Stanic M, Hundal A, Chan JNY, Urman D, Jordan CA, Hakem A, Espin R, Hao J, Krishnan R, Maass PG, Dickson BC, Hande MP, Pujana MA, Hakem R, Mekhail K. Shokrollahi M, et al. Nat Struct Mol Biol. 2024 Apr 17. doi: 10.1038/s41594-024-01286-7. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38632359
These factors collaborate with the linker of nucleoskeleton and cytoskeleton complex (LINC), nuclear pore complex (NPC) protein NUP153, nuclear lamina and kinesins KIF5B and KIF13B to generate DSB-capturing nuclear envelope tubules (dsbNETs). dsbNETs are partly supported by nucle …
These factors collaborate with the linker of nucleoskeleton and cytoskeleton complex (LINC), nuclear pore complex (NPC) protein NUP153, nucl …
Immune-based prognostic biomarkers associated with metastasis of osteosarcoma.
Ma T, Peng C, Wu D, Yang S, Ji L, Cheng Z, Gao C. Ma T, et al. Gen Physiol Biophys. 2023 Jan;42(1):1-12. doi: 10.4149/gpb_2022050. Gen Physiol Biophys. 2023. PMID: 36705300
Survival analysis revealed 8 prognostic genes (ANK3, EGR1, FBP1, FOS, KIFC3, MAOB, ISLR and MFAP4) from the 122 genes. RT-qPCR showed that all of these eight genes were differentially expressed between 143B and MNNG/HOS Cl cells. ...
Survival analysis revealed 8 prognostic genes (ANK3, EGR1, FBP1, FOS, KIFC3, MAOB, ISLR and MFAP4) from the 122 genes. RT-qPCR showed …
Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance.
Zou JX, Duan Z, Wang J, Sokolov A, Xu J, Chen CZ, Li JJ, Chen HW. Zou JX, et al. Mol Cancer Res. 2014 Apr;12(4):539-49. doi: 10.1158/1541-7786.MCR-13-0459. Epub 2014 Jan 3. Mol Cancer Res. 2014. PMID: 24391143 Free PMC article.
Through examining kinesin gene family expression in estrogen receptor (ER)-positive breast cancer cells, we found that estrogen stimulation of cancer cell proliferation involves a concerted regulation of specific kinesins. ...IMPLICATIONS: These findings support the …
Through examining kinesin gene family expression in estrogen receptor (ER)-positive breast cancer cells, we found that estrogen stimu …
17 results