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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 3
2002 3
2003 2
2004 5
2005 9
2006 5
2007 10
2008 9
2009 17
2010 13
2011 19
2012 14
2013 18
2014 21
2015 36
2016 24
2017 24
2018 40
2019 48
2020 46
2021 50
2022 52
2023 44
2024 22

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473 results

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Page 1
BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5.
Qin J, Zhou Z, Chen W, Wang C, Zhang H, Ge G, Shao M, You D, Fan Z, Xia H, Liu R, Chen C. Qin J, et al. Nat Commun. 2015 Sep 30;6:8471. doi: 10.1038/ncomms9471. Nat Commun. 2015. PMID: 26419610 Free PMC article.
The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitina …
The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell prolifera …
YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer.
Jiang D, Qiu T, Peng J, Li S, Tala, Ren W, Yang C, Wen Y, Chen CH, Sun J, Wu Y, Liu R, Zhou J, Wu K, Liu W, Mao X, Zhou Z, Chen C. Jiang D, et al. Cell Death Differ. 2022 Jun;29(6):1283-1295. doi: 10.1038/s41418-021-00920-x. Epub 2022 Jan 13. Cell Death Differ. 2022. PMID: 35022570 Free PMC article.
Y-box binding protein 1 (YB-1) is a well-known oncogene highly expressed in various cancers, including basal-like breast cancer (BLBC). Beyond its role as a transcription factor, YB-1 is newly defined as an epigenetic regulator involving RNA 5-methylcytosine. Howeve …
Y-box binding protein 1 (YB-1) is a well-known oncogene highly expressed in various cancers, including basal-like breast cancer …
The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition.
Liu P, Wang Z, Ou X, Wu P, Zhang Y, Wu S, Xiao X, Li Y, Ye F, Tang H. Liu P, et al. Mol Cancer. 2022 Oct 12;21(1):198. doi: 10.1186/s12943-022-01653-2. Mol Cancer. 2022. PMID: 36224562 Free PMC article.
BACKGROUND: Metastasis of breast cancer have caused the majority of cancer-related death worldwide. ...Meanwhile, KLF5 could upregulated CXCR4 transcriptionally to accelerate epithelial and mesenchymal transition of breast cancer. ...
BACKGROUND: Metastasis of breast cancer have caused the majority of cancer-related death worldwide. ...Meanwhile, KLF5 …
The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin.
Wang Z, Yang L, Wu P, Li X, Tang Y, Ou X, Zhang Y, Xiao X, Wang J, Tang H. Wang Z, et al. Mol Cancer. 2022 Jan 24;21(1):29. doi: 10.1186/s12943-022-01498-9. Mol Cancer. 2022. PMID: 35073911 Free PMC article.
BACKGROUND: Metastasis causes the majority of cancer-related deaths worldwide. Increasing studies have revealed that circRNAs are associated with the carcinogenesis and metastasis of many cancers. ...Therefore, a positive feedback loop comprising circROBO1/KLF5 …
BACKGROUND: Metastasis causes the majority of cancer-related deaths worldwide. Increasing studies have revealed that circRNAs are ass …
Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer.
Wei R, Zhou Y, Li C, Rychahou P, Zhang S, Titlow WB, Bauman G, Wu Y, Liu J, Wang C, Weiss HL, Evers BM, Wang Q. Wei R, et al. Cancer Res. 2022 Apr 15;82(8):1575-1588. doi: 10.1158/0008-5472.CAN-21-2778. Cancer Res. 2022. PMID: 35247887 Free PMC article.
The dynamic composition of the tumor microenvironment (TME) can markedly alter the response to targeted therapies for colorectal cancer. Cancer-associated fibroblasts (CAF) are major components of TMEs that can direct and induce infiltration of immunosuppressive cel …
The dynamic composition of the tumor microenvironment (TME) can markedly alter the response to targeted therapies for colorectal cancer …
KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer.
Wu Y, Chen S, Shao Y, Su Y, Li Q, Wu J, Zhu J, Wen H, Huang Y, Zheng Z, Chen X, Ju X, Huang S, Wu X, Hu Z. Wu Y, et al. Adv Sci (Weinh). 2023 Nov;10(31):e2304638. doi: 10.1002/advs.202304638. Epub 2023 Sep 13. Adv Sci (Weinh). 2023. PMID: 37702443 Free PMC article.
One major characteristic of tumor cells is the aberrant activation of epigenetic regulatory elements, which remodel the tumor transcriptome and ultimately promote cancer progression and drug resistance. However, the oncogenic functions and mechanisms of ovarian cancer …
One major characteristic of tumor cells is the aberrant activation of epigenetic regulatory elements, which remodel the tumor transcriptome …
The roles and regulation of the KLF5 transcription factor in cancers.
Luo Y, Chen C. Luo Y, et al. Cancer Sci. 2021 Jun;112(6):2097-2117. doi: 10.1111/cas.14910. Epub 2021 May 3. Cancer Sci. 2021. PMID: 33811715 Free PMC article. Review.
In response to multiple signaling pathways, various transcriptional modulation and posttranslational modifications affect the expression level and activity of KLF5. Several transgenic mouse models have revealed the physiological and pathological functions of KLF5 in …
In response to multiple signaling pathways, various transcriptional modulation and posttranslational modifications affect the expression lev …
Targeting Kruppel-like factor 5 (KLF5) for cancer therapy.
Gao Y, Ding Y, Chen H, Chen H, Zhou J. Gao Y, et al. Curr Top Med Chem. 2015;15(8):699-713. doi: 10.2174/1568026615666150302105052. Curr Top Med Chem. 2015. PMID: 25732792 Review.
The expression of KLF5 is frequently abnormal in human cancers and the functions of KLF5 are context dependent. Accumulating evidence suggests that KLF5 represents a novel therapeutic target for cancer therapy. In this review, we discuss the pot …
The expression of KLF5 is frequently abnormal in human cancers and the functions of KLF5 are context dependent. Accumul …
KLF5 inhibition potentiates anti-PD1 efficacy by enhancing CD8(+) T-cell-dependent antitumor immunity.
Wu Q, Liu Z, Gao Z, Luo Y, Li F, Yang C, Wang T, Meng X, Chen H, Li J, Kong Y, Dong C, Sun S, Chen C. Wu Q, et al. Theranostics. 2023 Feb 21;13(4):1381-1400. doi: 10.7150/thno.82182. eCollection 2023. Theranostics. 2023. PMID: 36923542 Free PMC article.
Exploring the strategies for tumor immunotherapy is highly dependent on the discovery of molecular mechanisms of tumor immune escape and potential therapeutic target. Kruppel-like Factor 5 (KLF5) is a cell-intrinsic oncogene to promote tumorigenesis. However, the cell-extr …
Exploring the strategies for tumor immunotherapy is highly dependent on the discovery of molecular mechanisms of tumor immune escape and pot …
Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer.
Huang Q, Liu M, Zhang D, Lin BB, Fu X, Zhang Z, Zhang B, Dong JT. Huang Q, et al. BMC Med. 2023 Feb 21;21(1):68. doi: 10.1186/s12916-023-02763-4. BMC Med. 2023. PMID: 36810084 Free PMC article.
Acetylated KLF5 (Ac-KLF5) and its downstream effectors are thus potential therapeutic targets for treating TGF-beta-induced bone metastasis in prostate cancer. ...CONCLUSIONS: NTZ is a potential therapeutic agent for bone metastasis induced by the TGF-beta/Ac …
Acetylated KLF5 (Ac-KLF5) and its downstream effectors are thus potential therapeutic targets for treating TGF-beta-induced bo …
473 results