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miR-181-5p/KLHL5 Promoted Proliferation and Migration of Gastric Cancer Through Activating METTL3-Mediated m6A Process.
Li R, Li Y, Wang Z, Suo R, Ma R, Zhang J. Li R, et al. Mol Biotechnol. 2023 Sep 21. doi: 10.1007/s12033-023-00877-x. Online ahead of print. Mol Biotechnol. 2023. PMID: 37733183
KLHL5 was a member of kelch-repeat protein family and was involved in the initiation of progression of a plethora of cancers. However, its specific role in gastric cancer was not explicitly illustrated. In this context, we aimed to investigate the biological …
KLHL5 was a member of kelch-repeat protein family and was involved in the initiation of progression of a plethora of cancers. …
KLHL5 Is a Prognostic-Related Biomarker and Correlated With Immune Infiltrates in Gastric Cancer.
Wu Q, Yin G, Lei J, Tian J, Lan A, Liu S. Wu Q, et al. Front Mol Biosci. 2020 Dec 10;7:599110. doi: 10.3389/fmolb.2020.599110. eCollection 2020. Front Mol Biosci. 2020. PMID: 33363208 Free PMC article.
Background: KLHL5 (Kelch Like Family Member 5) is differentially expressed in gastric cancer, but its correlation with prognosis and functioning mechanism in gastric cancer remain unclear. ...Especially, KLHL5 mRNA expression was upregulated and correl …
Background: KLHL5 (Kelch Like Family Member 5) is differentially expressed in gastric cancer, but its correlation with prognos …
KLHL5 knockdown increases cellular sensitivity to anticancer drugs.
Schleifer RJ, Li S, Nechtman W, Miller E, Bai S, Sharma A, She JX. Schleifer RJ, et al. Oncotarget. 2018 Dec 21;9(100):37429-37438. doi: 10.18632/oncotarget.26462. eCollection 2018 Dec 21. Oncotarget. 2018. PMID: 30647843 Free PMC article.
This study explores the relationship of expression of KLHL member, KLHL5, with the pharmacologic effect of anti-cancer drugs. KLHL5 knockdown decreased the proliferation and viability of cancer cells and sensitized cancer cells to numerous anti- …
This study explores the relationship of expression of KLHL member, KLHL5, with the pharmacologic effect of anti-cancer drugs. …
Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1.
Powell JA, Pitman MR, Zebol JR, Moretti PAB, Neubauer HA, Davies LT, Lewis AC, Dagley LF, Webb AI, Costabile M, Pitson SM. Powell JA, et al. Biochem J. 2019 Nov 15;476(21):3211-3226. doi: 10.1042/BCJ20190245. Biochem J. 2019. PMID: 31652307
Furthermore, using yeast two-hybrid screening, we identified Kelch-like protein 5 (KLHL5) as an important protein adaptor linking SK1 to the cullin 3 (Cul3) ubiquitin ligase complex. Notably, knockdown of KLHL5 or Cul3, use of a cullin inhibitor or a dominant-negati …
Furthermore, using yeast two-hybrid screening, we identified Kelch-like protein 5 (KLHL5) as an important protein adaptor linking SK1 …
Establishment and Characterization of Paired Primary and Peritoneal Seeding Human Colorectal Cancer Cell Lines: Identification of Genes That Mediate Metastatic Potential.
Kim SC, Hong CW, Jang SG, Kim YA, Yoo BC, Shin YK, Jeong SY, Ku JL, Park JG. Kim SC, et al. Transl Oncol. 2018 Oct;11(5):1232-1243. doi: 10.1016/j.tranon.2018.07.014. Epub 2018 Aug 14. Transl Oncol. 2018. PMID: 30114595 Free PMC article.
Microarray identified that there were five upregulated genes (CNN3, SORBS1, BST2, EPSTI1, and KLHL5) and two downregulated genes (TRY6 and STYL5) in the peritoneal metastatic cell lines. ...We suggest that CNN3 takes part in cell projection and movement, and the detection …
Microarray identified that there were five upregulated genes (CNN3, SORBS1, BST2, EPSTI1, and KLHL5) and two downregulated genes (TRY …
Identification of a functional circRNA-miRNA-mRNA regulatory network in infantile hemangioma by bioinformatics analysis.
Gu D, Lou H, Li Y, Xu G. Gu D, et al. Medicine (Baltimore). 2022 Sep 30;101(39):e30791. doi: 10.1097/MD.0000000000030791. Medicine (Baltimore). 2022. PMID: 36181115 Free PMC article.
Differentially expressed circRNA, miRNA, and mRNA were downloaded from the gene expression synthesis (GEO) microarray database (GSE98795, GSE69136, and GSE127487). Cancer-specific circRNA database (CSCD), miRDB and Targetscan were employed to predict the targets of RNA. .. …
Differentially expressed circRNA, miRNA, and mRNA were downloaded from the gene expression synthesis (GEO) microarray database (GSE98795, GS …