X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.
Matthews DA, Alden RA, Birktoft JJ, Freer ST, Kraut J.
Matthews DA, et al. Among authors: kraut j.
J Biol Chem. 1975 Sep 25;250(18):7120-6.
J Biol Chem. 1975.
PMID: 1165237
Free article.
The boron atom is coordinated tetrahedrally, with one of the two additional boronic acid oxygen atoms lying in the "oxyanion hole" and the other at the leaving group site identified in previous studies (ROBERTUS, J.D., Kraut, J. ALDEN, R.A., and BIRKTOFT, …
The boron atom is coordinated tetrahedrally, with one of the two additional boronic acid oxygen atoms lying in the "oxyanion hole" and the o …