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1998 1
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2022 8
2023 7
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45 results

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Page 1
IncRNA KTN1-AS1 Silencing Inhibits Non-Small-Cell Lung Cancer Cell Proliferation and KTN1-AS1 Expression Predicts Survival.
Wu F, Wang L, Xu L, Song S, Liang M. Wu F, et al. Crit Rev Eukaryot Gene Expr. 2022;32(2):39-46. doi: 10.1615/CritRevEukaryotGeneExpr.2021039172. Crit Rev Eukaryot Gene Expr. 2022. PMID: 35381130
Long noncoding RNA (lncRNA) KTN1 antisense RNA 1 (KTN1-AS1) has been characterized as an oncogenic lncRNA in liver cancer. In this study, we investigated the functions of KTN1-AS1 in non-small-cell lung cancer (NSCLC). A total of 66 patients (27 …
Long noncoding RNA (lncRNA) KTN1 antisense RNA 1 (KTN1-AS1) has been characterized as an oncogenic lncRNA in liver cancer …
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
Hu X, Xiang L, He D, Zhu R, Fang J, Wang Z, Cao K. Hu X, et al. Clin Sci (Lond). 2021 Feb 12;135(3):555-574. doi: 10.1042/CS20200908. Clin Sci (Lond). 2021. PMID: 33480975
RESULTS: KTN1-AS1 silencing inhibited the proliferation, invasion, and migration of bladder cancer cells, while KTN1-AS1 overexpression had the obvious opposite effects. ...CONCLUSION: Overall, our data support the idea that the lncRNA KTN1-AS1 promote …
RESULTS: KTN1-AS1 silencing inhibited the proliferation, invasion, and migration of bladder cancer cells, while KTN1-AS …
H3K27ac-activated lncRNA KTN1-AS1 aggravates tumor progression by miR-505-3p/ZNF326 axis in ovarian cancer.
Xie X, Wen Q, Yang X, Chen W, Liu Y, Liu W, Zhang T, Xu C, Shi K. Xie X, et al. Ann Transl Med. 2022 May;10(10):599. doi: 10.21037/atm-22-443. Ann Transl Med. 2022. PMID: 35722429 Free PMC article.
BACKGROUND: Numerous studies indicate that long noncoding RNA (lncRNA) is aberrantly expressed in ovarian cancer (OC). Our research investigated the regulatory role of lncRNA KTN1 antisense RNA1 (KTN1-AS1) in the progression of OC through the miR-505-3p/ZNF32 …
BACKGROUND: Numerous studies indicate that long noncoding RNA (lncRNA) is aberrantly expressed in ovarian cancer (OC). Our research i …
Long non-coding RNA KTN1-AS1 promotes progression in pancreatic cancer through regulating microRNA-23b-3p/high-mobility group box 2 axis.
Zhang ZB, Liu N. Zhang ZB, et al. Aging (Albany NY). 2021 Aug 30;13(16):20820-20835. doi: 10.18632/aging.203481. Epub 2021 Aug 30. Aging (Albany NY). 2021. PMID: 34461605 Free PMC article.
To explore the inhibitory effect of long non-coding RNA (LncRNA) antisense of KTN1 (KTN1-AS1) on the growth of pancreatic cancer (PC) cells by regulating the microRNA-23b-3p (miR-23b-3p)/high-mobility group box 2 (HMGB2) axis. The expression of KTN1-AS …
To explore the inhibitory effect of long non-coding RNA (LncRNA) antisense of KTN1 (KTN1-AS1) on the growth of pancreatic c …
Upregulating KTN1 promotes Hepatocellular Carcinoma progression.
Pan J, Chao NX, Zhang YY, Huang TM, Chen CX, Qin QH, Guo JH, Huang RS, Luo GR. Pan J, et al. J Cancer. 2021 Jun 11;12(16):4791-4809. doi: 10.7150/jca.55570. eCollection 2021. J Cancer. 2021. PMID: 34234850 Free PMC article.
Several cascades, including innate immune response, chemical carcinogenesis, and positive regulation of transcription by RNA polymerase II, were dramatically changed after KTN1 knockout. KTN1 primarily participated in the cell cycle, DNA replication, and microRNAs i …
Several cascades, including innate immune response, chemical carcinogenesis, and positive regulation of transcription by RNA polymerase II, …
ER proteins decipher the tubulin code to regulate organelle distribution.
Zheng P, Obara CJ, Szczesna E, Nixon-Abell J, Mahalingan KK, Roll-Mecak A, Lippincott-Schwartz J, Blackstone C. Zheng P, et al. Nature. 2022 Jan;601(7891):132-138. doi: 10.1038/s41586-021-04204-9. Epub 2021 Dec 15. Nature. 2022. PMID: 34912111 Free PMC article.
Dysregulation of endoplasmic reticulum morphology is tightly linked to neurologic disorders and cancer(5,6). Here we demonstrate that three membrane-bound endoplasmic reticulum proteins preferentially interact with different microtubule populations, with CLIMP63 binding ce …
Dysregulation of endoplasmic reticulum morphology is tightly linked to neurologic disorders and cancer(5,6). Here we demonstrate that …
LncRNA KTN1-AS1 promotes the progression of non-small cell lung cancer via sponging of miR-130a-5p and activation of PDPK1.
Li C, Zhao W, Pan X, Li X, Yan F, Liu S, Feng J, Lu J. Li C, et al. Oncogene. 2020 Sep;39(39):6157-6171. doi: 10.1038/s41388-020-01427-4. Epub 2020 Aug 20. Oncogene. 2020. PMID: 32820252
Non-small cell lung cancer (NSCLC) is the major cause of cancer-associated death worldwide, but its underlying mechanisms remain to be fully elucidated. Long noncoding RNAs (lncRNAs) are known to play an important role in the aberrant regulation of gene expression i …
Non-small cell lung cancer (NSCLC) is the major cause of cancer-associated death worldwide, but its underlying mechanisms rema …
Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity.
Gao L, Chen S, Hong M, Zhou W, Wang B, Qiu J, Xia J, Zhao P, Fu L, Wang J, Dai Y, Xie N, Yang Q, Huang HD, Gao X, Zou C. Gao L, et al. Signal Transduct Target Ther. 2021 Jul 5;6(1):250. doi: 10.1038/s41392-021-00652-x. Signal Transduct Target Ther. 2021. PMID: 34219129 Free PMC article.
Herein, we reported a novel function of factor Kinectin 1 (KTN1) as a carcinogenic promoter in TNBC. KTN1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer, and TNBC patients with high KTN1 exp …
Herein, we reported a novel function of factor Kinectin 1 (KTN1) as a carcinogenic promoter in TNBC. KTN1 expression in TNBC w …
LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis.
Zhang L, Wang L, Wang Y, Chen T, Liu R, Yang W, Liu Q, Tu K. Zhang L, et al. Biomed Pharmacother. 2019 Jan;109:1140-1147. doi: 10.1016/j.biopha.2018.10.105. Epub 2018 Nov 6. Biomed Pharmacother. 2019. PMID: 30551364 Free article.
Long non-coding RNAs (lncRNAs) are critical regulators in the tumorigenesis and metastasis of hepatocellular carcinoma (HCC). LncRNA KTN1 antisense RNA 1 (KTN1-AS1) has been reported to play an important role in colorectal cancer and correlates with unfavorab …
Long non-coding RNAs (lncRNAs) are critical regulators in the tumorigenesis and metastasis of hepatocellular carcinoma (HCC). LncRNA KTN1 …
KTN1-AS1, a SOX2-mediated lncRNA, activates epithelial-mesenchymal transition process in esophageal squamous cell carcinoma.
Chen L, Lu J, Xu T, Yan Z, Guo Y, Dong Z, Guo W. Chen L, et al. Sci Rep. 2022 Nov 23;12(1):20186. doi: 10.1038/s41598-022-24743-z. Sci Rep. 2022. PMID: 36418920 Free PMC article.
This study aimed to investigate the expression status, functional roles, and molecular mechanisms of KTN1-AS1 in the development of ESCC. Considerable upregulation of KTN1-AS1 was confirmed in esophageal cancer cells and ESCC tissues and its expression was as …
This study aimed to investigate the expression status, functional roles, and molecular mechanisms of KTN1-AS1 in the development of E …
45 results