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Page 1
Pharmacokinetics of Active Components From Guhong Injection in Normal and Pathological Rat Models of Cerebral Ischemia: A Comparative Study.
Yu L, Wan HF, Li C, Yang JH, Zhou HF, Wan HT, He Y. Yu L, et al. Front Pharmacol. 2018 May 15;9:493. doi: 10.3389/fphar.2018.00493. eCollection 2018. Front Pharmacol. 2018. PMID: 29867497 Free PMC article.
Plasma samples were collected from the jaw vein at different time points and subsequently tested by high-performance liquid chromatography (HPLC). Results: After administration of GHI, both aceglutamide and HSYA were immediately detected in the plasma. Ninety percent of …
Plasma samples were collected from the jaw vein at different time points and subsequently tested by high-performance liquid chromatography ( …
[Pharmacokinetics of main activ ingredients of Guhong injection in cerebral ischemia rats].
Fang YC, Wan HT, Yu L, Yin F, Yang JH, Zhou HF, He Y. Fang YC, et al. Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1940-1945. doi: 10.19540/j.cnki.cjcmm.20180206.001. Zhongguo Zhong Yao Za Zhi. 2018. PMID: 29902908 Chinese.
The concentration-time curves were drawn and pharmacokinetic data were obtained by DAS 3.2.6 software. The results showed that aceglutamide and HSYA showed good linear relationship within the ranges of 1.5-500 mg.L-1 (R2=0.997 5) and 0.33-40 mg.L-1 (R2=0.998 9) respectivel …
The concentration-time curves were drawn and pharmacokinetic data were obtained by DAS 3.2.6 software. The results showed that aceglutami …
Guhong injection mitigates myocardial ischemia/reperfusion injury by activating GST P to inhibit ASK1-JNK/p38 pathway.
Chen H, Zhou H, Yang J, Wan H, He Y. Chen H, et al. Phytomedicine. 2023 Jan;109:154603. doi: 10.1016/j.phymed.2022.154603. Epub 2022 Dec 13. Phytomedicine. 2023. PMID: 36610111
BACKGROUND: Guhong injection (GHI), a novel compound preparation that is composed of a chemical drug, namely aceglutamide, and the aqueous extract of safflower (Carthamus tinctorius L.), exhibits extreme antioxidative, antiapoptotic, anti-inflammatory, and neuroprotective …
BACKGROUND: Guhong injection (GHI), a novel compound preparation that is composed of a chemical drug, namely aceglutamide, and the aq …
Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion.
Zhang R, Yang N, Ji C, Zheng J, Liang Z, Hou CY, Liu YY, Zuo PP. Zhang R, et al. Restor Neurol Neurosci. 2015;33(5):741-59. doi: 10.3233/RNN-150509. Restor Neurol Neurosci. 2015. PMID: 26444640
Moreover, Aceglutamide significantly attenuated neuronal apoptosis in the SN. Meanwhile Aceglutamide treatment significantly inhibited the expression of TRAF1 and up-regulated the expression of P-Akt and Bcl-2/Bax ratio both in vitro and in vivo. ...These data provi …
Moreover, Aceglutamide significantly attenuated neuronal apoptosis in the SN. Meanwhile Aceglutamide treatment significantly i …
Influencing Factors of Hospital-Acquired Pneumonia Infection in the Middle-Aged and Elderly Patients With Schizophrenia.
Yang M, Li Q, Wang C, Li L, Xu M, Yan F, Chen W, Wan Y. Yang M, et al. Front Psychiatry. 2021 Oct 15;12:746791. doi: 10.3389/fpsyt.2021.746791. eCollection 2021. Front Psychiatry. 2021. PMID: 34721113 Free PMC article.
Multivariate logistic regression showed that quetiapine, clozapine, and olanzapine significantly increased the incidence of HAP (OR = 1.56, 95% CI = 1.05-2.32, p = 0.029; OR = 1.81, 95% CI = 1.26-2.60, p = 0.001; OR = 1.68, 95% CI = 1.16-2.42, p = 0.006). Antipsychotic drugs comb …
Multivariate logistic regression showed that quetiapine, clozapine, and olanzapine significantly increased the incidence of HAP (OR = 1.56, …
Enhanced thioredoxin, glutathione and Nrf2 antioxidant systems by safflower extract and aceglutamide attenuate cerebral ischaemia/reperfusion injury.
Zhang J, Zhou R, Xiang C, Fan F, Gao J, Zhang Y, Tang S, Xu H, Yang H. Zhang J, et al. J Cell Mol Med. 2020 May;24(9):4967-4980. doi: 10.1111/jcmm.15099. Epub 2020 Apr 7. J Cell Mol Med. 2020. PMID: 32266795 Free PMC article.
This study investigated the protective effect of safflower extract and aceglutamide (SAAG) against cerebral I/R injury through modulating multiple antioxidant systems of GSH, Trx and Nrf2 and identified each role of its component acegluatminde (AG) and safflower extract (S …
This study investigated the protective effect of safflower extract and aceglutamide (SAAG) against cerebral I/R injury through modula …
Guhong Injection Prevents Ischemic Stroke-Induced Neuro-Inflammation and Neuron Loss Through Regulation of C5ar1.
Zhang J, Zhou R, Cao G, Zhang Y, Xu H, Yang H. Zhang J, et al. Front Pharmacol. 2022 Mar 21;13:818245. doi: 10.3389/fphar.2022.818245. eCollection 2022. Front Pharmacol. 2022. PMID: 35387346 Free PMC article.
Furthermore, GHI and its major components hydroxysafflower yellow A (HSYA) and aceglutamide (AG) enhanced cell viability and reduced LDH level and C5AR1 expression in a C5A-induced Neuro-2a cell damage model. ...
Furthermore, GHI and its major components hydroxysafflower yellow A (HSYA) and aceglutamide (AG) enhanced cell viability and reduced …
Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish.
Wang Y, Wu H, Sheng H, Wang Y, Li X, Wang Y, Zhao L. Wang Y, et al. Biomed Pharmacother. 2022 Nov;155:113744. doi: 10.1016/j.biopha.2022.113744. Epub 2022 Sep 23. Biomed Pharmacother. 2022. PMID: 36156365 Free article.
We previously reported the positive effects of Guhong injection (GHI), composed of safflower extract and aceglutamide, in promoting functional recovery in ischemic stroke mice. ...
We previously reported the positive effects of Guhong injection (GHI), composed of safflower extract and aceglutamide, in promoting f …
Metabolic signatures in pericardial fluid and serum are associated with new-onset atrial fibrillation after isolated coronary artery bypass grafting.
Yang Y, Du Z, Fang M, Ma Y, Liu Y, Wang T, Han Z, Peng Z, Pan Y, Qin H, Qin Y, Jiang Y, Tu P, Guo X, Lu Y, Yang X, Hua K. Yang Y, et al. Transl Res. 2023 Jun;256:30-40. doi: 10.1016/j.trsl.2023.01.001. Epub 2023 Jan 11. Transl Res. 2023. PMID: 36638862
By using machine learning algorithms and regression models, a 4-metabolite (aceglutamide, ornithine, methionine, and arginine) risk prediction model was constructed and showed accurate performance in predicting POAF in both discovery and validation sets. ...
By using machine learning algorithms and regression models, a 4-metabolite (aceglutamide, ornithine, methionine, and arginine) risk p …
Effects of sodium polyacrylate (PANa) on acute esophagitis by gastric juice in rats.
Nakamura K, Ozawa Y, Furuta Y, Miyazaki H. Nakamura K, et al. Jpn J Pharmacol. 1982 Jun;32(3):445-56. doi: 10.1254/jjp.32.445. Jpn J Pharmacol. 1982. PMID: 7109349 Free article.
The preventive effect of PANa given intraesophageally on esophageal lesions induced by the intraesophageal application of gastric juice was more potent than aceglutamide aluminum and sodium alginate. Oral administration of PANa inhibited the formation of esophageal …
The preventive effect of PANa given intraesophageally on esophageal lesions induced by the intraesophageal application of gastric juice was …
45 results