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Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability.
NPJ Parkinsons Dis. 2024 Feb 23;10(1):41. doi: 10.1038/s41531-024-00648-8.
NPJ Parkinsons Dis. 2024.
PMID: 38395968
Free PMC article.
Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype.
Kearney PJ, Zhang Y, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shafer SA, Yue Z, Melikian HE.
Kearney PJ, et al. Among authors: kahuno e.
Res Sq [Preprint]. 2023 May 25:rs.3.rs-2944614. doi: 10.21203/rs.3.rs-2944614/v1.
Res Sq. 2023.
PMID: 37293098
Free PMC article.
Updated.
Preprint.
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Rit2 silencing in dopamine neurons drives a Parkinsonian phenotype.
Kearney PJ, Zhang Y, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shafer SA, Yue Z, Melikian HE.
Kearney PJ, et al. Among authors: kahuno e.
bioRxiv [Preprint]. 2023 Nov 13:2023.04.26.538430. doi: 10.1101/2023.04.26.538430.
bioRxiv. 2023.
PMID: 37162843
Free PMC article.
Preprint.
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Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function.
Kearney PJ, Bolden NC, Kahuno E, Conklin TL, Martin GE, Lubec G, Melikian HE.
Kearney PJ, et al. Among authors: kahuno e.
J Biol Chem. 2023 Feb;299(2):102900. doi: 10.1016/j.jbc.2023.102900. Epub 2023 Jan 12.
J Biol Chem. 2023.
PMID: 36640864
Free PMC article.
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Deconstructing behavioral neuropharmacology with cellular specificity.
Shields BC, Kahuno E, Kim C, Apostolides PF, Brown J, Lindo S, Mensh BD, Dudman JT, Lavis LD, Tadross MR.
Shields BC, et al. Among authors: kahuno e.
Science. 2017 Apr 7;356(6333):eaaj2161. doi: 10.1126/science.aaj2161.
Science. 2017.
PMID: 28385956
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