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Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Kaiser R, Leunig A, Pekayvaz K, Popp O, Joppich M, Polewka V, Escaig R, Anjum A, Hoffknecht ML, Gold C, Brambs S, Engel A, Stockhausen S, Knottenberg V, Titova A, Haji M, Scherer C, Muenchhoff M, Hellmuth JC, Saar K, Schubert B, Hilgendorff A, Schulz C, Kääb S, Zimmer R, Hübner N, Massberg S, Mertins P, Nicolai L, Stark K. Kaiser R, et al. JCI Insight. 2021 Sep 22;6(18):e150862. doi: 10.1172/jci.insight.150862. JCI Insight. 2021. PMID: 34403366 Free PMC article.
Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy.
Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, Muenchhoff M, Hellmuth JC, Ledderose S, Schulz H, Scherer C, Rudelius M, Zoller M, Höchter D, Keppler O, Teupser D, Zwißler B, von Bergwelt-Baildon M, Kääb S, Massberg S, Pekayvaz K, Stark K. Nicolai L, et al. Among authors: kaiser r. Circulation. 2020 Sep 22;142(12):1176-1189. doi: 10.1161/CIRCULATIONAHA.120.048488. Epub 2020 Jul 28. Circulation. 2020. PMID: 32755393 Free PMC article.
Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia.
Nicolai L, Leunig A, Brambs S, Kaiser R, Joppich M, Hoffknecht ML, Gold C, Engel A, Polewka V, Muenchhoff M, Hellmuth JC, Ruhle A, Ledderose S, Weinberger T, Schulz H, Scherer C, Rudelius M, Zoller M, Keppler OT, Zwißler B, von Bergwelt-Baildon M, Kääb S, Zimmer R, Bülow RD, von Stillfried S, Boor P, Massberg S, Pekayvaz K, Stark K. Nicolai L, et al. Among authors: kaiser r. J Thromb Haemost. 2021 Feb;19(2):574-581. doi: 10.1111/jth.15179. Epub 2020 Dec 20. J Thromb Haemost. 2021. PMID: 33217134 Free PMC article.
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Pekayvaz K, Leunig A, Kaiser R, Joppich M, Brambs S, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deák F, Puchinger K, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wieser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hoelscher M, Massberg S, Stark K, Nicolai L. Pekayvaz K, et al. Among authors: kaiser r. Nat Commun. 2022 Feb 23;13(1):1018. doi: 10.1038/s41467-022-28508-0. Nat Commun. 2022. PMID: 35197461 Free PMC article.
Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI.
Kaiser R, Escaig R, Kranich J, Hoffknecht ML, Anjum A, Polewka V, Mader M, Hu W, Belz L, Gold C, Titova A, Lorenz M, Pekayvaz K, Kääb S, Gaertner F, Stark K, Brocker T, Massberg S, Nicolai L. Kaiser R, et al. Blood. 2022 Jul 14;140(2):121-139. doi: 10.1182/blood.2021014914. Blood. 2022. PMID: 35472164 Free PMC article.
Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration.
Nicolai L, Leunig A, Pekayvaz K, Esefeld M, Anjum A, Rath J, Riedlinger E, Ehreiser V, Mader M, Eivers L, Hoffknecht ML, Zhang Z, Kugelmann D, Rossaro D, Escaig R, Kaiser R, Polewka V, Titova A, Petzold T, Spiekermann K, Iannacone M, Thiele T, Greinacher A, Stark K, Massberg S. Nicolai L, et al. Among authors: kaiser r. Blood. 2022 Aug 4;140(5):478-490. doi: 10.1182/blood.2021014712. Blood. 2022. PMID: 35486845 Free PMC article.
Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.
Bauer A, Pachl E, Hellmuth JC, Kneidinger N, Heydarian M, Frankenberger M, Stubbe HC, Ryffel B, Petrera A, Hauck SM, Behr J, Kaiser R, Scherer C, Deng L, Teupser D, Ahmidi N, Muenchhoff M, Schubert B, Hilgendorff A. Bauer A, et al. Among authors: kaiser r. Biochim Biophys Acta Mol Basis Dis. 2023 Feb;1869(2):166592. doi: 10.1016/j.bbadis.2022.166592. Epub 2022 Nov 1. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 36328146 Free PMC article.
Mechanosensing via a GpIIb/Src/14-3-3ζ axis critically regulates platelet migration in vascular inflammation.
Kaiser R, Anjum A, Kammerer L, Loew Q, Akhalkatsi A, Rossaro D, Escaig R, Droste Zu Senden A, Raude B, Lorenz M, Gold C, Pekayvaz K, Brocker T, Kranich J, Holch JW, Spiekermann K, Massberg S, Gaertner F, Nicolai L. Kaiser R, et al. Blood. 2023 Jun 15;141(24):2973-2992. doi: 10.1182/blood.2022019210. Blood. 2023. PMID: 37018659 Free PMC article.
1,672 results