Kalbfleisch JJ - Search Results

1

Development and profiling of mGlu₇ NAMs with a range of saturable inhibition of agonist responses in vitro.

Reed CW, Rodriguez AL, Kalbfleisch JJ, Seto M, Jenkins MT, Blobaum AL, Chang S, Lindsley CW, Niswender CM. Reed CW, et al. Among authors: kalbfleisch jj. Bioorg Med Chem Lett. 2022 Oct 15;74:128923. doi: 10.1016/j.bmcl.2022.128923. Epub 2022 Aug 6. Bioorg Med Chem Lett. 2022. PMID: 35944850 Free PMC article.

2

Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M₁ Positive Allosteric Modulators.

Engers JL, Bender AM, Kalbfleisch JJ, Cho HP, Lingenfelter KS, Luscombe VB, Han C, Melancon BJ, Blobaum AL, Dickerson JW, Rook JM, Niswender CM, Emmitte KA, Conn PJ, Lindsley CW. Engers JL, et al. Among authors: kalbfleisch jj. ACS Chem Neurosci. 2019 Mar 20;10(3):1035-1042. doi: 10.1021/acschemneuro.8b00311. Epub 2018 Aug 9. ACS Chem Neurosci. 2019. PMID: 30086237 Free PMC article.

3

Synthesis and SAR of a series of mGlu₇ NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core.

Kalbfleisch JJ, Reed CW, Park C, Spearing PK, Quitalig MC, Jenkins MT, Rodriguez AL, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Kalbfleisch JJ, et al. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127529. doi: 10.1016/j.bmcl.2020.127529. Epub 2020 Sep 2. Bioorg Med Chem Lett. 2020. PMID: 32890686 Free PMC article.

4

Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu₇ Positive Allosteric Modulator Tool Compound.

Reed CW, Kalbfleisch JJ, Wong MJ, Washecheck JP, Hunter A, Rodriguez AL, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Reed CW, et al. Among authors: kalbfleisch jj. ACS Med Chem Lett. 2020 Aug 20;11(9):1773-1779. doi: 10.1021/acsmedchemlett.0c00432. eCollection 2020 Sep 10. ACS Med Chem Lett. 2020. PMID: 32944146 Free PMC article.

5

Differential activity of mGlu₇ allosteric modulators provides evidence for mGlu_7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses.

Lin X, Fisher NM, Dogra S, Senter RK, Reed CW, Kalbfleisch JJ, Lindsley CW, Asher WB, Xiang Z, Niswender CM, Javitch JA. Lin X, et al. Among authors: kalbfleisch jj. J Biol Chem. 2022 Oct;298(10):102458. doi: 10.1016/j.jbc.2022.102458. Epub 2022 Sep 5. J Biol Chem. 2022. PMID: 36063995 Free PMC article.

6

Persistent challenges in the development of an mGlu₇ PAM in vivo tool compound: The discovery of VU6046980.

Kalbfleisch JJ, Rodriguez AL, Lei X, Weiss K, Blobaum AL, Boutaud O, Niswender CM, Lindsley CW. Kalbfleisch JJ, et al. Bioorg Med Chem Lett. 2023 Jan 15;80:129106. doi: 10.1016/j.bmcl.2022.129106. Epub 2022 Dec 15. Bioorg Med Chem Lett. 2023. PMID: 36528230 Free PMC article.

7

Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening.

Smith ST, Cassada JB, Von Bredow L, Erreger K, Webb EM, Trombley TA, Kalbfleisch JJ, Bender BJ, Zagol-Ikapitte I, Kramlinger VM, Bouchard JL, Mitchell SG, Tretbar M, Shoichet BK, Lindsley CW, Meiler J, Hamm HE. Smith ST, et al. Among authors: kalbfleisch jj. ACS Pharmacol Transl Sci. 2024 Mar 21;7(4):1086-1100. doi: 10.1021/acsptsci.3c00378. eCollection 2024 Apr 12. ACS Pharmacol Transl Sci. 2024. PMID: 38633591

8

Aqueous Photolysis of Benzobicyclon Hydrolysate.

Williams KL, Kaur R, McFall AS, Kalbfleisch J, Gladfelder JJ, Ball DB, Anastasio C, Tjeerdema RS. Williams KL, et al. Among authors: kalbfleisch j. J Agric Food Chem. 2018 Jun 6;66(22):5462-5472. doi: 10.1021/acs.jafc.8b01012. Epub 2018 May 22. J Agric Food Chem. 2018. PMID: 29754487

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