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Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.
Itoh M, Tamura A, Kanai S, Tanaka M, Kanamori Y, Shirakawa I, Ito A, Oka Y, Hidaka I, Takami T, Honda Y, Maeda M, Saito Y, Murata Y, Matozaki T, Nakajima A, Kataoka Y, Ogi T, Ogawa Y, Suganami T. Itoh M, et al. Among authors: kanai s. J Exp Med. 2023 Nov 6;220(11):e20220681. doi: 10.1084/jem.20220681. Epub 2023 Sep 19. J Exp Med. 2023. PMID: 37725372 Free PMC article.
CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis.
Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K, Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y. Itoh M, et al. Among authors: kanai s. JCI Insight. 2017 Nov 16;2(22):e92902. doi: 10.1172/jci.insight.92902. eCollection 2017 Nov 16. JCI Insight. 2017. PMID: 29202448 Free PMC article.
Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects.
Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T. Kawakubo M, et al. Among authors: kanai s. Sci Rep. 2020 Jan 22;10(1):983. doi: 10.1038/s41598-020-57935-6. Sci Rep. 2020. PMID: 31969650 Free PMC article.
The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.
Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y. Yamazaki Y, et al. Among authors: kanai s. Biochem J. 2010 Mar 15;427(1):171-8. doi: 10.1042/BJ20091346. Biochem J. 2010. PMID: 20088826
500 results