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The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity.
Espinoza JA, Zisi A, Kanellis DC, Carreras-Puigvert J, Henriksson M, Hühn D, Watanabe K, Helleday T, Lindström MS, Bartek J. Espinoza JA, et al. Among authors: kanellis dc. Cell Death Differ. 2020 Feb;27(2):773-789. doi: 10.1038/s41418-019-0387-5. Epub 2019 Jul 8. Cell Death Differ. 2020. PMID: 31285544 Free PMC article.
MDC1 maintains active elongation complexes of RNA polymerase II.
Pappas G, Munk SHN, Watanabe K, Thomas Q, Gál Z, Gram HH, Lee M, Gómez-Cabello D, Kanellis DC, Olivares-Chauvet P, Larsen DH, Gregersen LH, Maya-Mendoza A, Galanos P, Bartek J. Pappas G, et al. Among authors: kanellis dc. Cell Rep. 2023 Jan 31;42(1):111979. doi: 10.1016/j.celrep.2022.111979. Epub 2023 Jan 12. Cell Rep. 2023. PMID: 36640322 Free article.
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET.
Kanellis DC, Zisi A, Skrott Z, Lemmens B, Espinoza JA, Kosar M, Björkman A, Li X, Arampatzis S, Bartkova J, Andújar-Sánchez M, Fernandez-Capetillo O, Mistrik M, Lindström MS, Bartek J. Kanellis DC, et al. Cell Death Differ. 2023 Jul;30(7):1666-1678. doi: 10.1038/s41418-023-01167-4. Epub 2023 May 4. Cell Death Differ. 2023. PMID: 37142656 Free PMC article.
Tpl2 kinase signal transduction in inflammation and cancer.
Vougioukalaki M, Kanellis DC, Gkouskou K, Eliopoulos AG. Vougioukalaki M, et al. Among authors: kanellis dc. Cancer Lett. 2011 May 28;304(2):80-9. doi: 10.1016/j.canlet.2011.02.004. Epub 2011 Mar 5. Cancer Lett. 2011. PMID: 21377269 Review.
13 results