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Engineered antibody Fc variants with enhanced effector function.
Lazar GA, Dang W, Karki S, Vafa O, Peng JS, Hyun L, Chan C, Chung HS, Eivazi A, Yoder SC, Vielmetter J, Carmichael DF, Hayes RJ, Dahiyat BI. Lazar GA, et al. Among authors: karki s. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4005-10. doi: 10.1073/pnas.0508123103. Epub 2006 Mar 6. Proc Natl Acad Sci U S A. 2006. PMID: 16537476 Free PMC article.
Enhanced antibody half-life improves in vivo activity.
Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IW, Sproule TJ, Lazar GA, Roopenian DC, Desjarlais JR. Zalevsky J, et al. Among authors: karki s. Nat Biotechnol. 2010 Feb;28(2):157-9. doi: 10.1038/nbt.1601. Epub 2010 Jan 17. Nat Biotechnol. 2010. PMID: 20081867 Free PMC article.
Engineering fully human monoclonal antibodies from murine variable regions.
Bernett MJ, Karki S, Moore GL, Leung IW, Chen H, Pong E, Nguyen DH, Jacinto J, Zalevsky J, Muchhal US, Desjarlais JR, Lazar GA. Bernett MJ, et al. Among authors: karki s. J Mol Biol. 2010 Mar 12;396(5):1474-90. doi: 10.1016/j.jmb.2009.12.046. Epub 2010 Jan 4. J Mol Biol. 2010. PMID: 20045416
Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.
Tai YT, Horton HM, Kong SY, Pong E, Chen H, Cemerski S, Bernett MJ, Nguyen DH, Karki S, Chu SY, Lazar GA, Munshi NC, Desjarlais JR, Anderson KC, Muchhal US. Tai YT, et al. Among authors: karki s. Blood. 2012 Mar 1;119(9):2074-82. doi: 10.1182/blood-2011-06-364521. Epub 2012 Jan 13. Blood. 2012. PMID: 22246035 Free PMC article.
664 results