Kasahara Y - Search Results

1

GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling.

Matsumoto S, Yamamichi T, Shinzawa K, Kasahara Y, Nojima S, Kodama T, Obika S, Takehara T, Morii E, Okuyama H, Kikuchi A. Matsumoto S, et al. Among authors: kasahara y. Nat Commun. 2019 Aug 28;10(1):3882. doi: 10.1038/s41467-019-11533-x. Nat Commun. 2019. PMID: 31462641 Free PMC article.

2

Effect of 3'-end capping of aptamer with various 2',4'-bridged nucleotides: Enzymatic post-modification toward a practical use of polyclonal aptamers.

Kasahara Y, Kitadume S, Morihiro K, Kuwahara M, Ozaki H, Sawai H, Imanishi T, Obika S. Kasahara Y, et al. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1626-9. doi: 10.1016/j.bmcl.2010.01.028. Epub 2010 Jan 22. Bioorg Med Chem Lett. 2010. PMID: 20153191

3

Study on suitability of KOD DNA polymerase for enzymatic production of artificial nucleic acids using base/sugar modified nucleoside triphosphates.

Kuwahara M, Takano Y, Kasahara Y, Nara H, Ozaki H, Sawai H, Sugiyama A, Obika S. Kuwahara M, et al. Among authors: kasahara y. Molecules. 2010 Nov 12;15(11):8229-40. doi: 10.3390/molecules15118229. Molecules. 2010. PMID: 21076389 Free PMC article.

4

2',4'-BNA/LNA aptamers: CE-SELEX using a DNA-based library of full-length 2'-O,4'-C-methylene-bridged/linked bicyclic ribonucleotides.

Kasahara Y, Irisawa Y, Ozaki H, Obika S, Kuwahara M. Kasahara Y, et al. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1288-92. doi: 10.1016/j.bmcl.2012.12.093. Epub 2013 Jan 16. Bioorg Med Chem Lett. 2013. PMID: 23374873

5

Capillary electrophoresis-systematic evolution of ligands by exponential enrichment selection of base- and sugar-modified DNA aptamers: target binding dominated by 2'-O,4'-C-methylene-bridged/locked nucleic acid primer.

Kasahara Y, Irisawa Y, Fujita H, Yahara A, Ozaki H, Obika S, Kuwahara M. Kasahara Y, et al. Anal Chem. 2013 May 21;85(10):4961-7. doi: 10.1021/ac400058z. Epub 2013 May 10. Anal Chem. 2013. PMID: 23662585

6

In vitro selection of DNA-based aptamers that exhibit RNA-like conformations using a chimeric oligonucleotide library that contains two different xeno-nucleic acids.

Hagiwara K, Fujita H, Kasahara Y, Irisawa Y, Obika S, Kuwahara M. Hagiwara K, et al. Among authors: kasahara y. Mol Biosyst. 2015 Jan;11(1):71-6. doi: 10.1039/c4mb00436a. Epub 2014 Oct 17. Mol Biosyst. 2015. PMID: 25325213

7

Polymerase incorporation of a 2'-deoxynucleoside-5'-triphosphate bearing a 4-hydroxy-2-mercaptobenzimidazole nucleobase analogue.

Morihiro K, Hoshino H, Hasegawa O, Kasahara Y, Nakajima K, Kuwahara M, Tsunoda S, Obika S. Morihiro K, et al. Among authors: kasahara y. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2888-91. doi: 10.1016/j.bmcl.2015.05.075. Epub 2015 May 29. Bioorg Med Chem Lett. 2015. PMID: 26048797

8

Consecutive incorporation of functionalized nucleotides with amphiphilic side chains by novel KOD polymerase mutant.

Hoshino H, Kasahara Y, Fujita H, Kuwahara M, Morihiro K, Tsunoda SI, Obika S. Hoshino H, et al. Among authors: kasahara y. Bioorg Med Chem Lett. 2016 Jan 15;26(2):530-533. doi: 10.1016/j.bmcl.2015.11.079. Epub 2015 Nov 22. Bioorg Med Chem Lett. 2016. PMID: 26627581

9

[Design of antisense oligonucleotides].

Obika S, Kasahara Y. Obika S, et al. Among authors: kasahara y. Nihon Yakurigaku Zasshi. 2016 Aug;148(2):100-4. doi: 10.1254/fpj.148.100. Nihon Yakurigaku Zasshi. 2016. PMID: 27478049 Review. Japanese. No abstract available.

10

Biological applications of xeno nucleic acids.

Morihiro K, Kasahara Y, Obika S. Morihiro K, et al. Among authors: kasahara y. Mol Biosyst. 2017 Jan 31;13(2):235-245. doi: 10.1039/c6mb00538a. Mol Biosyst. 2017. PMID: 27827481 Review.

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