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Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers.
Yeh RF, Gaver VE, Patterson KB, Rezk NL, Baxter-Meheux F, Blake MJ, Eron JJ Jr, Klein CE, Rublein JC, Kashuba AD. Yeh RF, et al. Among authors: kashuba ad. J Acquir Immune Defic Syndr. 2006 May;42(1):52-60. doi: 10.1097/01.qai.0000219774.20174.64. J Acquir Immune Defic Syndr. 2006. PMID: 16639344
Simple and rapid quantification of the non-nucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz in human blood plasma using high-performance liquid chromatography with ultraviolet absorbance detection.
Rezk NL, Tidwell RR, Kashuba AD. Rezk NL, et al. Among authors: kashuba ad. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Jul 5;774(1):79-88. doi: 10.1016/s1570-0232(02)00210-6. J Chromatogr B Analyt Technol Biomed Life Sci. 2002. PMID: 12052725
Kaletra (lopinavir/ritonavir).
Corbett AH, Lim ML, Kashuba AD. Corbett AH, et al. Among authors: kashuba ad. Ann Pharmacother. 2002 Jul-Aug;36(7-8):1193-203. doi: 10.1345/aph.1A363. Ann Pharmacother. 2002. PMID: 12086554 Review.
Absence of sustained hyperlactatemia in HIV-infected patients with risk factors for mitochondrial toxicity.
Wohl DA, Pilcher CD, Evans S, Revuelta M, McComsey G, Yang Y, Zackin R, Alston B, Welch S, Basar M, Kashuba A, Kondo P, Martinez A, Giardini J, Quinn J, Littles M, Wingfield H, Koletar SL; Adult AIDS Clinical Trials Group A5129 Team. Wohl DA, et al. J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):274-8. doi: 10.1097/00126334-200403010-00008. J Acquir Immune Defic Syndr. 2004. PMID: 15076242 Clinical Trial.
275 results