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NAADP+ is an agonist of the human P2Y11 purinergic receptor.
Moreschi I, Bruzzone S, Bodrato N, Usai C, Guida L, Nicholas RA, Kassack MU, Zocchi E, De Flora A. Moreschi I, et al. Among authors: kassack mu. Cell Calcium. 2008 Apr;43(4):344-55. doi: 10.1016/j.ceca.2007.06.006. Epub 2007 Aug 17. Cell Calcium. 2008. PMID: 17707504
Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.
Vaughan KR, Stokes L, Prince LR, Marriott HM, Meis S, Kassack MU, Bingle CD, Sabroe I, Surprenant A, Whyte MK. Vaughan KR, et al. Among authors: kassack mu. J Immunol. 2007 Dec 15;179(12):8544-53. doi: 10.4049/jimmunol.179.12.8544. J Immunol. 2007. PMID: 18056402 Free PMC article.
NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells.
Meis S, Hamacher A, Hongwiset D, Marzian C, Wiese M, Eckstein N, Royer HD, Communi D, Boeynaems JM, Hausmann R, Schmalzing G, Kassack MU. Meis S, et al. Among authors: kassack mu. J Pharmacol Exp Ther. 2010 Jan;332(1):238-47. doi: 10.1124/jpet.109.157750. Epub 2009 Oct 8. J Pharmacol Exp Ther. 2010. PMID: 19815812
The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups.
Hausmann R, Rettinger J, Gerevich Z, Meis S, Kassack MU, Illes P, Lambrecht G, Schmalzing G. Hausmann R, et al. Among authors: kassack mu. Mol Pharmacol. 2006 Jun;69(6):2058-67. doi: 10.1124/mol.106.022665. Epub 2006 Mar 21. Mol Pharmacol. 2006. PMID: 16551782
131 results