Kassahun K - Search Results

1

Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters.

Chu XY, Liang Y, Cai X, Cuevas-Licea K, Rippley RK, Kassahun K, Shou M, Braun MP, Doss GA, Anari MR, Evers R. Chu XY, et al. Among authors: kassahun k. Pharm Res. 2009 Feb;26(2):459-68. doi: 10.1007/s11095-008-9799-5. Epub 2008 Dec 11. Pharm Res. 2009. PMID: 19082692

2

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA. Kassahun K, et al. Chem Res Toxicol. 2001 Jan;14(1):62-70. doi: 10.1021/tx000180q. Chem Res Toxicol. 2001. PMID: 11170509

3

Quantitation of geometric isomers of a phosphodiesterase inhibitor in rat and monkey plasma using liquid chromatography-tandem mass spectrometry.

Liang Y, Zhang R, Adarayan E, Adamson G, Zhao JJ, Kassahun K, Emary WB. Liang Y, et al. Among authors: kassahun k. J Pharm Biomed Anal. 2006 Jun 16;41(4):1293-8. doi: 10.1016/j.jpba.2006.02.016. Epub 2006 Mar 23. J Pharm Biomed Anal. 2006. PMID: 16563689

4

Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.

Kassahun K, Skordos K, McIntosh I, Slaughter D, Doss GA, Baillie TA, Yost GS. Kassahun K, et al. Chem Res Toxicol. 2005 Sep;18(9):1427-37. doi: 10.1021/tx050092b. Chem Res Toxicol. 2005. PMID: 16167835

5

Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor.

Kassahun K, McIntosh IS, Shou M, Walsh DJ, Rodeheffer C, Slaughter DE, Geer LA, Halpin RA, Agrawal N, Rodrigues AD. Kassahun K, et al. Drug Metab Dispos. 2001 Jun;29(6):813-20. Drug Metab Dispos. 2001. PMID: 11353749

6

Prednisone has no effect on the pharmacokinetics of CYP3A4 metabolized drugs - midazolam and odanacatib.

Marcantonio EE, Ballard J, Gibson CR, Kassahun K, Palamanda J, Tang C, Evers R, Liu C, Zajic S, Mahon C, Mostoller K, Hreniuk D, Mehta A, Morris D, Wagner JA, Stoch SA. Marcantonio EE, et al. Among authors: kassahun k. J Clin Pharmacol. 2014 Nov;54(11):1280-9. doi: 10.1002/jcph.338. Epub 2014 Jun 25. J Clin Pharmacol. 2014. PMID: 24895078

7

Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme.

Kassahun K, McIntosh I, Cui D, Hreniuk D, Merschman S, Lasseter K, Azrolan N, Iwamoto M, Wagner JA, Wenning LA. Kassahun K, et al. Drug Metab Dispos. 2007 Sep;35(9):1657-63. doi: 10.1124/dmd.107.016196. Epub 2007 Jun 25. Drug Metab Dispos. 2007. PMID: 17591678

8

Disposition and metabolism of the cathepsin K inhibitor odanacatib in humans.

Kassahun K, McIntosh I, Koeplinger K, Sun L, Talaty JE, Miller DL, Dixon R, Zajic S, Stoch SA. Kassahun K, et al. Drug Metab Dispos. 2014 May;42(5):818-27. doi: 10.1124/dmd.113.056580. Epub 2014 Feb 19. Drug Metab Dispos. 2014. PMID: 24553380 Clinical Trial.

9

Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions.

Kumar S, Kassahun K, Tschirret-Guth RA, Mitra K, Baillie TA. Kumar S, et al. Among authors: kassahun k. Curr Opin Drug Discov Devel. 2008 Jan;11(1):43-52. Curr Opin Drug Discov Devel. 2008. PMID: 18175266 Review.

10

Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation.

Iwamoto M, Kassahun K, Troyer MD, Hanley WD, Lu P, Rhoton A, Petry AS, Ghosh K, Mangin E, DeNoia EP, Wenning LA, Stone JA, Gottesdiener KM, Wagner JA. Iwamoto M, et al. Among authors: kassahun k. J Clin Pharmacol. 2008 Feb;48(2):209-14. doi: 10.1177/0091270007310382. Epub 2007 Dec 12. J Clin Pharmacol. 2008. PMID: 18077730 Clinical Trial.

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