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Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta.
Akeboshi H, Chiba Y, Kasahara Y, Takashiba M, Takaoka Y, Ohsawa M, Tajima Y, Kawashima I, Tsuji D, Itoh K, Sakuraba H, Jigami Y. Akeboshi H, et al. Among authors: kawashima i. Appl Environ Microbiol. 2007 Aug;73(15):4805-12. doi: 10.1128/AEM.00463-07. Epub 2007 Jun 8. Appl Environ Microbiol. 2007. PMID: 17557860 Free PMC article.
Corrective effect on Fabry mice of yeast recombinant human alpha-galactosidase with N-linked sugar chains suitable for lysosomal delivery.
Sakuraba H, Chiba Y, Kotani M, Kawashima I, Ohsawa M, Tajima Y, Takaoka Y, Jigami Y, Takahashi H, Hirai Y, Shimada T, Hashimoto Y, Ishii K, Kobayashi T, Watabe K, Fukushige T, Kanzaki T. Sakuraba H, et al. Among authors: kawashima i. J Hum Genet. 2006;51(4):341-352. doi: 10.1007/s10038-006-0369-6. Epub 2006 Mar 11. J Hum Genet. 2006. PMID: 16532254
Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease.
Tajima Y, Kawashima I, Tsukimura T, Sugawara K, Kuroda M, Suzuki T, Togawa T, Chiba Y, Jigami Y, Ohno K, Fukushige T, Kanekura T, Itoh K, Ohashi T, Sakuraba H. Tajima Y, et al. Among authors: kawashima i. Am J Hum Genet. 2009 Nov;85(5):569-80. doi: 10.1016/j.ajhg.2009.09.016. Epub 2009 Oct 22. Am J Hum Genet. 2009. PMID: 19853240 Free PMC article.
Highly phosphomannosylated enzyme replacement therapy for GM2 gangliosidosis.
Tsuji D, Akeboshi H, Matsuoka K, Yasuoka H, Miyasaki E, Kasahara Y, Kawashima I, Chiba Y, Jigami Y, Taki T, Sakuraba H, Itoh K. Tsuji D, et al. Among authors: kawashima i. Ann Neurol. 2011 Apr;69(4):691-701. doi: 10.1002/ana.22262. Epub 2010 Dec 8. Ann Neurol. 2011. PMID: 21520232
231 results