Kazi A - Search Results

1

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis.

Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG. Takahashi Y, et al. Among authors: kazi a. Mol Cell Biol. 2005 Nov;25(21):9369-82. doi: 10.1128/MCB.25.21.9369-9382.2005. Mol Cell Biol. 2005. PMID: 16227588 Free PMC article.

2

A novel beta-lactam antibiotic activates tumor cell apoptotic program by inducing DNA damage.

Smith DM, Kazi A, Smith L, Long TE, Heldreth B, Turos E, Dou QP. Smith DM, et al. Among authors: kazi a. Mol Pharmacol. 2002 Jun;61(6):1348-58. doi: 10.1124/mol.61.6.1348. Mol Pharmacol. 2002. PMID: 12021396

3

Inhibition of bcl-x(l) phosphorylation by tea polyphenols or epigallocatechin-3-gallate is associated with prostate cancer cell apoptosis.

Kazi A, Smith DM, Zhong Q, Dou QP. Kazi A, et al. Mol Pharmacol. 2002 Oct;62(4):765-71. doi: 10.1124/mol.62.4.765. Mol Pharmacol. 2002. PMID: 12237322

4

Association of mitochondrial calpain activation with increased expression and autolysis of calpain small subunit in an early stage of apoptosis.

Daniel KG, Anderson JS, Zhong Q, Kazi A, Gupta P, Dou QP. Daniel KG, et al. Among authors: kazi a. Int J Mol Med. 2003 Aug;12(2):247-52. Int J Mol Med. 2003. PMID: 12851726

5

Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63. doi: 10.1128/MCB.01029-08. Epub 2009 Feb 9. Mol Cell Biol. 2009. PMID: 19204084 Free PMC article.

6

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells.

Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Kazi A, et al. Cell Cycle. 2009 Jun 15;8(12):1940-51. doi: 10.4161/cc.8.12.8798. Epub 2009 Jun 20. Cell Cycle. 2009. PMID: 19471122 Free PMC article.

7

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors.

Lawrence HR, Kazi A, Luo Y, Kendig R, Ge Y, Jain S, Daniel K, Santiago D, Guida WC, Sebti SM. Lawrence HR, et al. Among authors: kazi a. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. doi: 10.1016/j.bmc.2010.06.038. Epub 2010 Jun 18. Bioorg Med Chem. 2010. PMID: 20621484 Free PMC article.

8

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM. Kazi A, et al. J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638. Epub 2010 Dec 9. J Biol Chem. 2011. PMID: 21148306 Free PMC article.

9

Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma.

O'Neil BH, Goff LW, Kauh JS, Strosberg JR, Bekaii-Saab TS, Lee RM, Kazi A, Moore DT, Learoyd M, Lush RM, Sebti SM, Sullivan DM. O'Neil BH, et al. Among authors: kazi a. J Clin Oncol. 2011 Jun 10;29(17):2350-6. doi: 10.1200/JCO.2010.33.9432. Epub 2011 Apr 25. J Clin Oncol. 2011. PMID: 21519015 Free PMC article. Clinical Trial.

10

Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.

Ge Y, Kazi A, Marsilio F, Luo Y, Jain S, Brooks W, Daniel KG, Guida WC, Sebti SM, Lawrence HR. Ge Y, et al. Among authors: kazi a. J Med Chem. 2012 Mar 8;55(5):1978-98. doi: 10.1021/jm201118h. Epub 2012 Feb 14. J Med Chem. 2012. PMID: 22220566 Free PMC article.

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