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A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction.
Lee SI, Conrad T, Jones SM, Lagziel A, Starost MF, Belyantseva IA, Friedman TB, Morell RJ. Lee SI, et al. Hear Res. 2013 Jun;300:1-9. doi: 10.1016/j.heares.2013.02.009. Epub 2013 Mar 22. Hear Res. 2013. PMID: 23528307 Free PMC article.
KCNA10 is a voltage gated potassium channel that is expressed in the inner ear. The localization and function of KCNA10 was studied in a mutant mouse, B6-Kcna10(TM45), in which the single protein coding exon of Kcna10 was replaced with a beta-galactosi …
KCNA10 is a voltage gated potassium channel that is expressed in the inner ear. The localization and function of KCNA10 was st …
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.
Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV. Lang R, et al. Am J Physiol Renal Physiol. 2000 Jun;278(6):F1013-21. doi: 10.1152/ajprenal.2000.278.6.F1013. Am J Physiol Renal Physiol. 2000. PMID: 10836990 Free article.
Because Kcn1 did not express well (peak current in Xenopus laevis oocytes of 0.3 microA at +60 mV), the human homolog (KCNA10) was isolated, and its expression was optimized in oocytes. KCNA10 mediates voltage-gated K(+) currents that exhibit minimal steady-state in …
Because Kcn1 did not express well (peak current in Xenopus laevis oocytes of 0.3 microA at +60 mV), the human homolog (KCNA10) was is …
Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.
Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV. Yao X, et al. J Am Soc Nephrol. 2002 Dec;13(12):2831-9. doi: 10.1097/01.asn.0000036866.37886.c5. J Am Soc Nephrol. 2002. PMID: 12444201
The aim of this study was to establish the cellular and subcellular localization of KCNA10 in kidney and vascular tissues. An anti-KCNA10 polyclonal antibody was generated, and immunocytochemical studies were performed on rat kidney. ...The data suggest that KCNA …
The aim of this study was to establish the cellular and subcellular localization of KCNA10 in kidney and vascular tissues. An anti- …
Genomic localization of the human gene for KCNA10, a cGMP-activated K channel.
Orias M, Bray-Ward P, Curran ME, Keating MT, Desir GV. Orias M, et al. Genomics. 1997 May 15;42(1):33-7. doi: 10.1006/geno.1997.4712. Genomics. 1997. PMID: 9177773 Free article.
Since KCNA10 has the potential to be useful in candidate gene analysis of inherited diseases, the human gene for KCNA10 was characterized. ...We found that YAC 818b9 contains human KCNA10. These data indicate human KCNA10 maps to 1p13.1 and resides wit …
Since KCNA10 has the potential to be useful in candidate gene analysis of inherited diseases, the human gene for KCNA10 was ch …
Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti.
Carlisle FA, Steel KP, Lewis MA. Carlisle FA, et al. Gene Expr Patterns. 2012 May-Jun;12(5-6):172-9. doi: 10.1016/j.gep.2012.03.001. Epub 2012 Mar 16. Gene Expr Patterns. 2012. PMID: 22446089 Free PMC article.
Here we describe the expression pattern of three genes not previously studied in the inner ear in mice at a range of ages both embryonic and early postnatal. Kcna10, a tetrameric Shaker-like potassium channel, is expressed strongly in the hair cells themselves. ...
Here we describe the expression pattern of three genes not previously studied in the inner ear in mice at a range of ages both embryonic and …
Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.
Tian S, Liu W, Wu Y, Rafi H, Segal AS, Desir GV. Tian S, et al. Am J Physiol Renal Physiol. 2002 Jul;283(1):F142-9. doi: 10.1152/ajprenal.00258.2001. Am J Physiol Renal Physiol. 2002. PMID: 12060596 Free article.
However, when coinjected with KCNA10, it increased KCNA10 current expression by nearly threefold. ...KCNA4B can be coimmunoprecipitated with the COOH terminus of KCNA10 and full-length KCNA10. It encodes a soluble protein (141 aa) with no amino acid ho …
However, when coinjected with KCNA10, it increased KCNA10 current expression by nearly threefold. ...KCNA4B can be coimmunopre …
Association of Single Nucleotide Polymorphisms in KCNA10 and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of Unknown Etiology in Central Indian Patients.
Kumari R, Tiwari S, Atlani M, Anirudhan A, Goel SK, Kumar A. Kumari R, et al. Biochem Genet. 2023 Aug;61(4):1548-1566. doi: 10.1007/s10528-023-10335-7. Epub 2023 Jan 25. Biochem Genet. 2023. PMID: 36696070
We used the odds ratio (OR) to assess the association of individual SNPs, rs34970857 of KCNA10, rs6066043 of SLC13A3, and rs2910164 of miR-146a with CKDu and CKD susceptibility. In the case of rs34970857 of the KCNA10 gene, we noted a significantly increased OR for …
We used the odds ratio (OR) to assess the association of individual SNPs, rs34970857 of KCNA10, rs6066043 of SLC13A3, and rs2910164 o …
The potassium channel subunit K(V)1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.
Martin HR, Lysakowski A, Eatock RA. Martin HR, et al. bioRxiv [Preprint]. 2023 Nov 21:2023.11.21.563853. doi: 10.1101/2023.11.21.563853. bioRxiv. 2023. PMID: 38045305 Free PMC article. Preprint.
Mature type I HCs express a large and very unusual potassium conductance, g(K,L), which activates negative to resting potential, confers very negative resting potentials and low input resistances, and enhances an unusual non-quantal transmission from type I cells onto their calyc …
Mature type I HCs express a large and very unusual potassium conductance, g(K,L), which activates negative to resting potential, confers ver …
Whole-exome sequencing and electrophysiological study reveal a novel loss-of-function mutation of KCNA10 in epinephrine provoked long QT syndrome with familial history of sudden cardiac death.
Huang S, Chen J, Song M, Yu Y, Geng J, Lin D, Yang J, Wu J, Li K, Yu Y, Wang J, Hu L, Shan Q, Wang J, Chen P, Chen F. Huang S, et al. Leg Med (Tokyo). 2023 May;62:102245. doi: 10.1016/j.legalmed.2023.102245. Epub 2023 Mar 20. Leg Med (Tokyo). 2023. PMID: 36965351
Whole-exome sequencing and bioinformatic analysis based on pedigree revealed that a novel missense mutation KCNA10 (c.1397G>A/Arg466Gln) was the potential genetic lesion. Sanger sequencing was performed to confirm the whole-exome sequencing results. This mutation result …
Whole-exome sequencing and bioinformatic analysis based on pedigree revealed that a novel missense mutation KCNA10 (c.1397G>A/Arg4 …
Authentication of differential gene expression in oral squamous cell carcinoma using machine learning applications.
Pratama R, Hwang JJ, Lee JH, Song G, Park HR. Pratama R, et al. BMC Oral Health. 2021 May 29;21(1):281. doi: 10.1186/s12903-021-01642-9. BMC Oral Health. 2021. PMID: 34051764 Free PMC article.
The analysis showed differentially expressed genes in multiwise comparisons of various types of SCCs, such as KCNA10, FOSL2, and PRDM16, and extracted leader genes from pairwise comparisons were FGF20, DLC1, and ZNF705D....
The analysis showed differentially expressed genes in multiwise comparisons of various types of SCCs, such as KCNA10, FOSL2, and PRDM …
18 results