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GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
Elife. 2021 Apr 29;10:e68274. doi: 10.7554/eLife.68274.
Elife. 2021.
PMID: 33913808
Free PMC article.
We therefore examined the localization and function of Cav2.3, GBRs, and KCTDs in this pathway in mice. We show in heterologous cells that KCTD8 and KCTD12b directly bind to Cav2.3 and that KCTD8 potentiates Cav2.3 currents in the absence of GBRs. In the rostral IPN, KCTD8 …
We therefore examined the localization and function of Cav2.3, GBRs, and KCTDs in this pathway in mice. We show in heterologous cells that K …
KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents.
Fritzius T, Turecek R, Seddik R, Kobayashi H, Tiao J, Rem PD, Metz M, Kralikova M, Bouvier M, Gassmann M, Bettler B.
Fritzius T, et al.
J Neurosci. 2017 Feb 1;37(5):1162-1175. doi: 10.1523/JNEUROSCI.2181-16.2016. Epub 2016 Dec 21.
J Neurosci. 2017.
PMID: 28003345
Free PMC article.
GABA(B) receptors were shown to associate with homo-oligomers of auxiliary KCTD8, KCTD12, KCTD12b, and KCTD16 subunits (named after their T1 K(+)-channel tetramerization domain) that regulate G-protein signaling of the receptor. ...
GABA(B) receptors were shown to associate with homo-oligomers of auxiliary KCTD8, KCTD12, KCTD12b, and KCTD16 subunits (named after t …
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