Keen N - Search Results

1

Mitotic drivers--inhibitors of the Aurora B Kinase.

Keen N, Taylor S. Keen N, et al. Cancer Metastasis Rev. 2009 Jun;28(1-2):185-95. doi: 10.1007/s10555-009-9184-9. Cancer Metastasis Rev. 2009. PMID: 19189202 Free article. Review.

2

Aurora-kinase inhibitors as anticancer agents.

Keen N, Taylor S. Keen N, et al. Nat Rev Cancer. 2004 Dec;4(12):927-36. doi: 10.1038/nrc1502. Nat Rev Cancer. 2004. PMID: 15573114 Review.

3

Validating Aurora B as an anti-cancer drug target.

Girdler F, Gascoigne KE, Eyers PA, Hartmuth S, Crafter C, Foote KM, Keen NJ, Taylor SS. Girdler F, et al. J Cell Sci. 2006 Sep 1;119(Pt 17):3664-75. doi: 10.1242/jcs.03145. Epub 2006 Aug 15. J Cell Sci. 2006. PMID: 16912073

4

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.

Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS. Ditchfield C, et al. Among authors: keen n. J Cell Biol. 2003 Apr 28;161(2):267-80. doi: 10.1083/jcb.200208091. J Cell Biol. 2003. PMID: 12719470 Free PMC article.

5

The Ipl1/Aurora kinase family: methods of inhibition and functional analysis in mammalian cells.

Ditchfield C, Keen N, Taylor SS. Ditchfield C, et al. Among authors: keen n. Methods Mol Biol. 2005;296:371-81. doi: 10.1385/1-59259-857-9:371. Methods Mol Biol. 2005. PMID: 15576945

6

AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis.

Wilkinson RW, Odedra R, Heaton SP, Wedge SR, Keen NJ, Crafter C, Foster JR, Brady MC, Bigley A, Brown E, Byth KF, Barrass NC, Mundt KE, Foote KM, Heron NM, Jung FH, Mortlock AA, Boyle FT, Green S. Wilkinson RW, et al. Clin Cancer Res. 2007 Jun 15;13(12):3682-8. doi: 10.1158/1078-0432.CCR-06-2979. Clin Cancer Res. 2007. PMID: 17575233

7

Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.

Foote KM, Mortlock AA, Heron NM, Jung FH, Hill GB, Pasquet G, Brady MC, Green S, Heaton SP, Kearney S, Keen NJ, Odedra R, Wedge SR, Wilkinson RW. Foote KM, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1904-9. doi: 10.1016/j.bmcl.2008.02.002. Epub 2008 Feb 7. Bioorg Med Chem Lett. 2008. PMID: 18294849

8

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.

Mortlock AA, Foote KM, Heron NM, Jung FH, Pasquet G, Lohmann JJ, Warin N, Renaud F, De Savi C, Roberts NJ, Johnson T, Dousson CB, Hill GB, Perkins D, Hatter G, Wilkinson RW, Wedge SR, Heaton SP, Odedra R, Keen NJ, Crafter C, Brown E, Thompson K, Brightwell S, Khatri L, Brady MC, Kearney S, McKillop D, Rhead S, Parry T, Green S. Mortlock AA, et al. Among authors: keen nj. J Med Chem. 2007 May 3;50(9):2213-24. doi: 10.1021/jm061335f. Epub 2007 Mar 21. J Med Chem. 2007. PMID: 17373783

9

Progress in the development of selective inhibitors of Aurora kinases.

Mortlock A, Keen NJ, Jung FH, Heron NM, Foote KM, Wilkinson R, Green S. Mortlock A, et al. Curr Top Med Chem. 2005;5(2):199-213. doi: 10.2174/1568026053507651. Curr Top Med Chem. 2005. PMID: 15853647 Corrected and republished. Review.

10

Progress in the development of selective inhibitors of aurora kinases.

Mortlock AA, Keen NJ, Jung FH, Heron NM, Foote KM, Wilkinson RW, Green S. Mortlock AA, et al. Curr Top Med Chem. 2005;5(8):807-21. doi: 10.2174/1568026054637719. Curr Top Med Chem. 2005. PMID: 16101420 Review.

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