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Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment.
Meng X, Yao D, Imaizumi K, Chen X, Kelley KW, Reis N, Thete MV, Arjun McKinney A, Kulkarni S, Panagiotakos G, Bassik MC, Pașca SP. Meng X, et al. Among authors: kelley kw. Nature. 2023 Oct;622(7982):359-366. doi: 10.1038/s41586-023-06564-w. Epub 2023 Sep 27. Nature. 2023. PMID: 37758944 Free PMC article.
Maturation and circuit integration of transplanted human cortical organoids.
Revah O, Gore F, Kelley KW, Andersen J, Sakai N, Chen X, Li MY, Birey F, Yang X, Saw NL, Baker SW, Amin ND, Kulkarni S, Mudipalli R, Cui B, Nishino S, Grant GA, Knowles JK, Shamloo M, Huguenard JR, Deisseroth K, Pașca SP. Revah O, et al. Among authors: kelley kw. Nature. 2022 Oct;610(7931):319-326. doi: 10.1038/s41586-022-05277-w. Epub 2022 Oct 12. Nature. 2022. PMID: 36224417 Free PMC article.
Generation of Functional Human 3D Cortico-Motor Assembloids.
Andersen J, Revah O, Miura Y, Thom N, Amin ND, Kelley KW, Singh M, Chen X, Thete MV, Walczak EM, Vogel H, Fan HC, Paşca SP. Andersen J, et al. Among authors: kelley kw. Cell. 2020 Dec 23;183(7):1913-1929.e26. doi: 10.1016/j.cell.2020.11.017. Epub 2020 Dec 16. Cell. 2020. PMID: 33333020 Free PMC article.
Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.
Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Molofsky AV, et al. Among authors: kelley kw. Nature. 2014 May 8;509(7499):189-94. doi: 10.1038/nature13161. Epub 2014 Apr 28. Nature. 2014. PMID: 24776795 Free PMC article.
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV Jr, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. Zhang J, et al. Among authors: kelley kw. Nature. 2020 Dec;588(7838):459-465. doi: 10.1038/s41586-020-2709-7. Epub 2020 Aug 31. Nature. 2020. PMID: 32866962 Free PMC article.
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.
Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Sorrells SF, et al. Among authors: kelley kw. Nature. 2018 Mar 15;555(7696):377-381. doi: 10.1038/nature25975. Epub 2018 Mar 7. Nature. 2018. PMID: 29513649 Free PMC article.
Transcriptional architecture of the human brain.
Kelley KW, Oldham MC. Kelley KW, et al. Nat Neurosci. 2015 Dec;18(12):1699-701. doi: 10.1038/nn.4178. Nat Neurosci. 2015. PMID: 26605877 No abstract available.
322 results