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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
2008 1
2009 4
2010 2
2011 2
2012 1
2016 1
2018 1
2019 2
2020 2
2021 2
2022 2
2023 1
2024 0

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20 results

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Page 1
Biliary atresia.
Hartley JL, Davenport M, Kelly DA. Hartley JL, et al. Lancet. 2009 Nov 14;374(9702):1704-13. doi: 10.1016/S0140-6736(09)60946-6. Lancet. 2009. PMID: 19914515 Review.
Researchers are focused on identification of relevant genetic and immune factors and understanding serum and hepatic factors that drive liver fibrosis after Kasai portoenterostomy. These factors might become therapeutic targets to halt the inevitable development of cirrhos …
Researchers are focused on identification of relevant genetic and immune factors and understanding serum and hepatic factors that drive live …
Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics.
Kelly K, West AB. Kelly K, et al. Front Neurosci. 2020 Aug 6;14:807. doi: 10.3389/fnins.2020.00807. eCollection 2020. Front Neurosci. 2020. PMID: 32903744 Free PMC article. Review.
Historically, there have been few successes in the development of therapies that might slow or halt the progression of neurodegenerative diseases. Over the past few decades of biomedical research, retrospective analyses suggest the broad integration of informative biomarke …
Historically, there have been few successes in the development of therapies that might slow or halt the progression of neurodegenerat …
Cellular rewiring in lethal prostate cancer: the architect of drug resistance.
Carceles-Cordon M, Kelly WK, Gomella L, Knudsen KE, Rodriguez-Bravo V, Domingo-Domenech J. Carceles-Cordon M, et al. Nat Rev Urol. 2020 May;17(5):292-307. doi: 10.1038/s41585-020-0298-8. Epub 2020 Mar 16. Nat Rev Urol. 2020. PMID: 32203305 Free PMC article. Review.
However, most of these combination regimens were developed empirically and, despite offering survival benefits, are not enough to halt disease progression. Thus, the development of effective therapeutic strategies that target the mechanisms involved in the acquisition of d …
However, most of these combination regimens were developed empirically and, despite offering survival benefits, are not enough to halt …
Best practice guidance for the diagnosis and management of cystic fibrosis-associated liver disease.
Debray D, Kelly D, Houwen R, Strandvik B, Colombo C. Debray D, et al. J Cyst Fibros. 2011 Jun;10 Suppl 2:S29-36. doi: 10.1016/S1569-1993(11)60006-4. J Cyst Fibros. 2011. PMID: 21658639 Free article. Review.
Annual screening for liver disease is recommended to detect pre-symptomatic signs and initiate ursodeoxycholic acid therapy, which might halt disease progression. Liver disease should be considered if at least two of the following variables are present: abnormal physical e …
Annual screening for liver disease is recommended to detect pre-symptomatic signs and initiate ursodeoxycholic acid therapy, which might …
Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.
Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA. Connelly S, et al. Curr Opin Struct Biol. 2010 Feb;20(1):54-62. doi: 10.1016/j.sbi.2009.12.009. Epub 2010 Feb 3. Curr Opin Struct Biol. 2010. PMID: 20133122 Free PMC article. Review.
These so-called TTR kinetic stabilizers have been designed using structure-based principles and one of these has recently been shown to halt the progression of a human TTR amyloid disease in a clinical trial, providing the first pharmacologic evidence that the process of a …
These so-called TTR kinetic stabilizers have been designed using structure-based principles and one of these has recently been shown to h …
Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis.
Coelho T, Merlini G, Bulawa CE, Fleming JA, Judge DP, Kelly JW, Maurer MS, Planté-Bordeneuve V, Labaudinière R, Mundayat R, Riley S, Lombardo I, Huertas P. Coelho T, et al. Neurol Ther. 2016 Jun;5(1):1-25. doi: 10.1007/s40120-016-0040-x. Epub 2016 Feb 19. Neurol Ther. 2016. PMID: 26894299 Free PMC article. Review.
The TTR amyloidoses present with a spectrum of manifestations, encompassing progressive neuropathy and/or cardiomyopathy. Until recently, the only accepted treatment to halt progression of hereditary TTR amyloidosis was liver transplantation, which replaces the hepatic sou …
The TTR amyloidoses present with a spectrum of manifestations, encompassing progressive neuropathy and/or cardiomyopathy. Until recently, th …
Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention.
Solomon JP, Page LJ, Balch WE, Kelly JW. Solomon JP, et al. Crit Rev Biochem Mol Biol. 2012 May-Jun;47(3):282-96. doi: 10.3109/10409238.2012.661401. Epub 2012 Feb 24. Crit Rev Biochem Mol Biol. 2012. PMID: 22360545 Free PMC article. Review.
We use what we have learned from our biochemical studies, as well as insight from mouse and human pathology to propose therapeutic strategies that may halt the progression of FAF....
We use what we have learned from our biochemical studies, as well as insight from mouse and human pathology to propose therapeutic strategie …
Aliskiren: a novel renoprotective agent or simply an alternative to ACE inhibitors?
Wiggins KJ, Kelly DJ. Wiggins KJ, et al. Kidney Int. 2009 Jul;76(1):23-31. doi: 10.1038/ki.2009.105. Epub 2009 Apr 15. Kidney Int. 2009. PMID: 19367328 Free article. Review.
Although these measures attenuate the inexorable progression to renal failure, they do not halt it. One limiting factor may be feedback effects of ACEis and ARBs, such as increased plasma renin activity. ...
Although these measures attenuate the inexorable progression to renal failure, they do not halt it. One limiting factor may be feedba …
Guard cells control hypocotyl elongation through HXK1, HY5, and PIF4.
Kelly G, Brandsma D, Egbaria A, Stein O, Doron-Faigenboim A, Lugassi N, Belausov E, Zemach H, Shaya F, Carmi N, Sade N, Granot D. Kelly G, et al. Commun Biol. 2021 Jun 21;4(1):765. doi: 10.1038/s42003-021-02283-y. Commun Biol. 2021. PMID: 34155329 Free PMC article.
Upon exposure to light, photoreceptors that are activated by blue and red light halt elongation by preventing the degradation of the hypocotyl-elongation inhibitor HY5 and by inhibiting the activity of the elongation-promoting transcription factors PIFs. ...
Upon exposure to light, photoreceptors that are activated by blue and red light halt elongation by preventing the degradation of the …
Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system.
Houser MC, Uriarte Huarte O, Wallings RL, Keating CE, MacPherson KP, Herrick MK, Kannarkat GT, Kelly SD, Chang J, Varvel NH, Rexach JE, Tansey MG. Houser MC, et al. Front Immunol. 2022 Dec 22;13:1056417. doi: 10.3389/fimmu.2022.1056417. eCollection 2022. Front Immunol. 2022. PMID: 36618392 Free PMC article.
DISCUSSION: Our data suggest that PGRN and GPNMB jointly regulate the peripheral and the central immune system in a sex-specific manner; thus, understanding their associated mechanisms could pave the way for developing new neuroprotective strategies to modulate central and periph …
DISCUSSION: Our data suggest that PGRN and GPNMB jointly regulate the peripheral and the central immune system in a sex-specific manner; thu …
20 results