Kenny JR - Search Results

1

Exploring concepts of in vitro time-dependent CYP inhibition assays.

Stresser DM, Mao J, Kenny JR, Jones BC, Grime K. Stresser DM, et al. Among authors: kenny jr. Expert Opin Drug Metab Toxicol. 2014 Feb;10(2):157-74. doi: 10.1517/17425255.2014.856882. Epub 2013 Nov 21. Expert Opin Drug Metab Toxicol. 2014. PMID: 24256452 Review.

2

Pharmacokinetic consequences of time-dependent inhibition using the isolated perfused rat liver model.

Kenny JR, Grime K. Kenny JR, et al. Xenobiotica. 2006 May;36(5):351-65. doi: 10.1080/00498250600637946. Xenobiotica. 2006. PMID: 16854776

3

Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma.

Mao J, Tay S, Khojasteh CS, Chen Y, Hop CE, Kenny JR. Mao J, et al. Among authors: kenny jr. Pharm Res. 2016 May;33(5):1204-19. doi: 10.1007/s11095-016-1865-9. Epub 2016 Feb 11. Pharm Res. 2016. PMID: 26869174

4

Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells.

McGinnity DF, Zhang G, Kenny JR, Hamilton GA, Otmani S, Stams KR, Haney S, Brassil P, Stresser DM, Riley RJ. McGinnity DF, et al. Among authors: kenny jr. Drug Metab Dispos. 2009 Jun;37(6):1259-68. doi: 10.1124/dmd.109.026526. Epub 2009 Mar 23. Drug Metab Dispos. 2009. PMID: 19307295

5

Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.

Hariparsad N, Ramsden D, Palamanda J, Dekeyser JG, Fahmi OA, Kenny JR, Einolf H, Mohutsky M, Pardon M, Siu YA, Chen L, Sinz M, Jones B, Walsky R, Dallas S, Balani SK, Zhang G, Buckley D, Tweedie D. Hariparsad N, et al. Among authors: kenny jr. Drug Metab Dispos. 2017 Oct;45(10):1049-1059. doi: 10.1124/dmd.116.074567. Epub 2017 Jun 23. Drug Metab Dispos. 2017. PMID: 28646080

6

Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.

Kenny JR, Chen L, McGinnity DF, Grime K, Shakesheff KM, Thomson B, Riley R. Kenny JR, et al. Xenobiotica. 2008 Dec;38(12):1500-17. doi: 10.1080/00498250802495846. Xenobiotica. 2008. PMID: 18989830

7

Evaluation of time-dependent cytochrome p450 inhibition in a high-throughput, automated assay: introducing a novel area under the curve shift approach.

Mukadam S, Tay S, Tran D, Wang L, Delarosa EM, Khojasteh SC, Halladay JS, Kenny JR. Mukadam S, et al. Among authors: kenny jr. Drug Metab Lett. 2012 Mar;6(1):43-53. doi: 10.2174/187231212800229309. Drug Metab Lett. 2012. PMID: 22372554

8

Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug-Drug Interaction Prediction.

Chen Y, Ma F, Lu T, Budha N, Jin JY, Kenny JR, Wong H, Hop CE, Mao J. Chen Y, et al. Among authors: kenny jr. Clin Pharmacokinet. 2016 Jun;55(6):735-49. doi: 10.1007/s40262-015-0352-5. Clin Pharmacokinet. 2016. PMID: 26692192

9

Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.

McGinnity DF, Berry AJ, Kenny JR, Grime K, Riley RJ. McGinnity DF, et al. Among authors: kenny jr. Drug Metab Dispos. 2006 Aug;34(8):1291-300. doi: 10.1124/dmd.106.009969. Epub 2006 May 5. Drug Metab Dispos. 2006. PMID: 16679385

10

Drug-drug interaction potential of marketed oncology drugs: in vitro assessment of time-dependent cytochrome P450 inhibition, reactive metabolite formation and drug-drug interaction prediction.

Kenny JR, Mukadam S, Zhang C, Tay S, Collins C, Galetin A, Khojasteh SC. Kenny JR, et al. Pharm Res. 2012 Jul;29(7):1960-76. doi: 10.1007/s11095-012-0724-6. Epub 2012 Mar 14. Pharm Res. 2012. PMID: 22415140

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

63 results

Search Page