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Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats.
Ginn JD, Bosanac T, Chen R, Cywin C, Hickey E, Kashem M, Kerr S, Kugler S, Li X, Prokopowicz A 3rd, Schlyer S, Smith JD, Turner MR, Wu F, Young ER. Ginn JD, et al. Among authors: kerr s. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5153-6. doi: 10.1016/j.bmcl.2010.07.014. Epub 2010 Aug 1. Bioorg Med Chem Lett. 2010. PMID: 20678931
Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
Takahashi H, Riether D, Bartolozzi A, Bosanac T, Berger V, Binetti R, Broadwater J, Chen Z, Crux R, De Lombaert S, Dave R, Dines JA, Fadra-Khan T, Flegg A, Garrigou M, Hao MH, Huber J, Hutzler JM, Kerr S, Kotey A, Liu W, Lo HY, Loke PL, Mahaney PE, Morwick TM, Napier S, Olague A, Pack E, Padyana AK, Thomson DS, Tye H, Wu L, Zindell RM, Abeywardane A, Simpson T. Takahashi H, et al. Among authors: kerr s. J Med Chem. 2015 Feb 26;58(4):1669-90. doi: 10.1021/jm501185j. Epub 2015 Feb 11. J Med Chem. 2015. PMID: 25671290
Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice.
Sun P, Bartlett CS, Zheng C, Bigwarfe T, Grant JM, MacDougall M, Berger V, Kerr S, Qian HS, McHugh M, Chen H, Zhang X, Carpenter ML, Robinson HN, Miglietta J, Lamla T, Fryer RM. Sun P, et al. Among authors: kerr s. J Pharmacol Exp Ther. 2022 Sep;382(3):266-276. doi: 10.1124/jpet.121.001067. Epub 2022 Jul 2. J Pharmacol Exp Ther. 2022. PMID: 35779860
VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis.
Low S, Wu H, Jerath K, Tibolla A, Fogal B, Conrad R, MacDougall M, Kerr S, Berger V, Dave R, Villalona J, Pantages L, Ahlberg J, Li H, Van Hoorick D, Ververken C, Broadwater J, Waterman A, Singh S, Kroe-Barrett R. Low S, et al. Among authors: kerr s. MAbs. 2020 Jan-Dec;12(1):1709322. doi: 10.1080/19420862.2019.1709322. MAbs. 2020. PMID: 31924119 Free PMC article.
Combined PET/DCE-MRI in a Rabbit Model of Atherosclerosis: Integrated Quantification of Plaque Inflammation, Permeability, and Burden During Treatment With a Leukotriene A4 Hydrolase Inhibitor.
Calcagno C, Lairez O, Hawkins J, Kerr SW, Dugas MS, Simpson T, Epskamp J, Robson PM, Eldib M, Bander I, K-Raman P, Ramachandran S, Pruzan A, Kaufman A, Mani V, Ehlgen A, Niessen HG, Broadwater J, Fayad ZA. Calcagno C, et al. Among authors: kerr sw. JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 2):291-301. doi: 10.1016/j.jcmg.2017.11.030. JACC Cardiovasc Imaging. 2018. PMID: 29413439 Free article.
1,052 results