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Genome-wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations.
Herrera-Luis E, Espuela-Ortiz A, Lorenzo-Diaz F, Keys KL, Mak ACY, Eng C, Huntsman S, Villar J, Rodriguez-Santana JR, Burchard EG, Pino-Yanes M. Herrera-Luis E, et al. Among authors: keys kl. Pediatr Allergy Immunol. 2021 Jan;32(1):106-115. doi: 10.1111/pai.13337. Epub 2020 Sep 14. Pediatr Allergy Immunol. 2021. PMID: 32841424 Free PMC article.
Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.
Mak ACY, White MJ, Eckalbar WL, Szpiech ZA, Oh SS, Pino-Yanes M, Hu D, Goddard P, Huntsman S, Galanter J, Wu AC, Himes BE, Germer S, Vogel JM, Bunting KL, Eng C, Salazar S, Keys KL, Liberto J, Nuckton TJ, Nguyen TA, Torgerson DG, Kwok PY, Levin AM, Celedón JC, Forno E, Hakonarson H, Sleiman PM, Dahlin A, Tantisira KG, Weiss ST, Serebrisky D, Brigino-Buenaventura E, Farber HJ, Meade K, Lenoir MA, Avila PC, Sen S, Thyne SM, Rodriguez-Cintron W, Winkler CA, Moreno-Estrada A, Sandoval K, Rodriguez-Santana JR, Kumar R, Williams LK, Ahituv N, Ziv E, Seibold MA, Darnell RB, Zaitlen N, Hernandez RD, Burchard EG; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Mak ACY, et al. Among authors: keys kl. Am J Respir Crit Care Med. 2018 Jun 15;197(12):1552-1564. doi: 10.1164/rccm.201712-2529OC. Am J Respir Crit Care Med. 2018. PMID: 29509491 Free PMC article.
Genetic Determinants of Telomere Length in African American Youth.
Zeiger AM, White MJ, Eng C, Oh SS, Witonsky J, Goddard PC, Contreras MG, Elhawary JR, Hu D, Mak ACY, Lee EY, Keys KL, Samedy LA, Risse-Adams O, Magaña J, Huntsman S, Salazar S, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Farber HJ, Bibbins-Domingo K, Borrell LN, Burchard EG. Zeiger AM, et al. Among authors: keys kl. Sci Rep. 2018 Sep 5;8(1):13265. doi: 10.1038/s41598-018-31238-3. Sci Rep. 2018. PMID: 30185882 Free PMC article.
Ambient air pollution, asthma drug response, and telomere length in African American youth.
Lee EY, Oh SS, White MJ, Eng CS, Elhawary JR, Borrell LN, Nuckton TJ, Zeiger AM, Keys KL, Mak ACY, Hu D, Huntsman S, Contreras MG, Samedy LA, Goddard PC, Salazar SL, Brigino-Buenaventura EN, Davis A, Meade KE, LeNoir MA, Lurmann FW, Burchard EG, Eisen EA, Balmes JR. Lee EY, et al. Among authors: keys kl. J Allergy Clin Immunol. 2019 Sep;144(3):839-845.e10. doi: 10.1016/j.jaci.2019.06.009. Epub 2019 Jun 24. J Allergy Clin Immunol. 2019. PMID: 31247265 Free PMC article.
De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Celedón JC, Soto-Quiros ME, Avila L, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, Zöllner S, O'Connell JR, Mitchell BD; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Population Genetics Working Group; O'Connor TD. Kessler MD, et al. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2560-2569. doi: 10.1073/pnas.1902766117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964835 Free PMC article.
Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction.
Mak ACY, Sajuthi S, Joo J, Xiao S, Sleiman PM, White MJ, Lee EY, Saef B, Hu D, Gui H, Keys KL, Lurmann F, Jain D, Abecasis G, Kang HM, Nickerson DA, Germer S, Zody MC, Winterkorn L, Reeves C, Huntsman S, Eng C, Salazar S, Oh SS, Gilliland FD, Chen Z, Kumar R, Martínez FD, Wu AC, Ziv E, Hakonarson H, Himes BE, Williams LK, Seibold MA, Burchard EG. Mak ACY, et al. Among authors: keys kl. Genetics. 2020 Jul;215(3):869-886. doi: 10.1534/genetics.120.303231. Epub 2020 Apr 23. Genetics. 2020. PMID: 32327564 Free PMC article.
Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.
Lee EY, Mak ACY, Hu D, Sajuthi S, White MJ, Keys KL, Eckalbar W, Bonser L, Huntsman S, Urbanek C, Eng C, Jain D, Abecasis G, Kang HM, Germer S, Zody MC, Nickerson DA, Erle D, Ziv E, Rodriguez-Santana J, Seibold MA, Burchard EG. Lee EY, et al. Among authors: keys kl. Am J Respir Crit Care Med. 2020 Oct 1;202(7):962-972. doi: 10.1164/rccm.202002-0351OC. Am J Respir Crit Care Med. 2020. PMID: 32459537 Free PMC article.
An epistatic interaction between pre-natal smoke exposure and socioeconomic status has a significant impact on bronchodilator drug response in African American youth with asthma.
Magaña J, Contreras MG, Keys KL, Risse-Adams O, Goddard PC, Zeiger AM, Mak ACY, Elhawary JR, Samedy-Bates LA, Lee E, Thakur N, Hu D, Eng C, Salazar S, Huntsman S, Hu T, Burchard EG, White MJ. Magaña J, et al. Among authors: keys kl. BioData Min. 2020 Jul 3;13:7. doi: 10.1186/s13040-020-00218-7. eCollection 2020. BioData Min. 2020. PMID: 32636926 Free PMC article.
On the cross-population generalizability of gene expression prediction models.
Keys KL, Mak ACY, White MJ, Eckalbar WL, Dahl AW, Mefford J, Mikhaylova AV, Contreras MG, Elhawary JR, Eng C, Hu D, Huntsman S, Oh SS, Salazar S, Lenoir MA, Ye JC, Thornton TA, Zaitlen N, Burchard EG, Gignoux CR. Keys KL, et al. PLoS Genet. 2020 Aug 14;16(8):e1008927. doi: 10.1371/journal.pgen.1008927. eCollection 2020 Aug. PLoS Genet. 2020. PMID: 32797036 Free PMC article.
23 results