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Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.
Gediya LK, Belosay A, Khandelwal A, Purushottamachar P, Njar VC. Gediya LK, et al. Among authors: khandelwal a. Bioorg Med Chem. 2008 Mar 15;16(6):3352-60. doi: 10.1016/j.bmc.2007.12.007. Epub 2007 Dec 8. Bioorg Med Chem. 2008. PMID: 18166465 Free PMC article.
Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.
Gediya LK, Khandelwal A, Patel J, Belosay A, Sabnis G, Mehta J, Purushottamachar P, Njar VC. Gediya LK, et al. Among authors: khandelwal a. J Med Chem. 2008 Jul 10;51(13):3895-904. doi: 10.1021/jm8001839. Epub 2008 Jun 11. J Med Chem. 2008. PMID: 18543902
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer.
Vasaitis T, Belosay A, Schayowitz A, Khandelwal A, Chopra P, Gediya LK, Guo Z, Fang HB, Njar VC, Brodie AM. Vasaitis T, et al. Among authors: khandelwal a. Mol Cancer Ther. 2008 Aug;7(8):2348-57. doi: 10.1158/1535-7163.MCT-08-0230. Mol Cancer Ther. 2008. PMID: 18723482 Free PMC article.
VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.
Godbole AM, Ramalingam S, Ramamurthy VP, Khandelwal A, Bruno RD, Upreti VV, Gediya LK, Purushottamachar P, Mbatia HW, Addya S, Ambulos N, Njar VC. Godbole AM, et al. Among authors: khandelwal a. Eur J Pharmacol. 2014 Jul 5;734:98-104. doi: 10.1016/j.ejphar.2014.04.004. Epub 2014 Apr 12. Eur J Pharmacol. 2014. PMID: 24726842 Free PMC article.
485 results