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Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.
Kharasch ED, Thummel KE, Mhyre J, Lillibridge JH. Kharasch ED, et al. Clin Pharmacol Ther. 1993 Jun;53(6):643-50. doi: 10.1038/clpt.1993.85. Clin Pharmacol Ther. 1993. PMID: 8513656
Clinical P450 2E1 activity was assessed by the 6-hydroxylation of chlorzoxazone, a metabolic pathway catalyzed selectively by P450 2E1. ...The efficacy of single-dose disulfiram as an inhibitor of human P450 …
Clinical P450 2E1 activity was assessed by the 6-hydroxylation of chlorzoxazone, a metabolic pathway cata …
Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans.
Emery MG, Jubert C, Thummel KE, Kharasch ED. Emery MG, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):213-9. J Pharmacol Exp Ther. 1999. PMID: 10490907 Clinical Trial.
Disulfiram (DSF) is a mechanism-based inhibitor of cytochrome P-450 2E1 (CYP2E1), resulting in loss of CYP2E1 protein and activity, which may be useful in preventing CYP2E1-mediated xenobiotic toxicity. ...Oral chlorzoxazone (CLZ) was used as the selective in …
Disulfiram (DSF) is a mechanism-based inhibitor of cytochrome P-450 2E1 (CYP2E1), resulting in loss of CYP2E1 protein and acti …