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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 2
1999 1
2000 1
2001 2
2002 3
2003 3
2004 3
2005 2
2006 4
2007 7
2008 4
2009 19
2010 23
2011 22
2012 33
2013 30
2014 38
2015 31
2016 35
2017 38
2018 43
2019 50
2020 40
2021 45
2022 46
2023 51
2024 17

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539 results

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Page 1
ALK-rearrangement in non-small-cell lung cancer (NSCLC).
Du X, Shao Y, Qin HF, Tai YH, Gao HJ. Du X, et al. Thorac Cancer. 2018 Apr;9(4):423-430. doi: 10.1111/1759-7714.12613. Epub 2018 Feb 28. Thorac Cancer. 2018. PMID: 29488330 Free PMC article. Review.
More than 19 different ALK fusion partners have been discovered in NSCLC, including EML4, KIF5B, KLC1, and TPR. Most of these ALK fusions in NSCLC patients respond well to the ALK inhibitor, crizotinib. ...
More than 19 different ALK fusion partners have been discovered in NSCLC, including EML4, KIF5B, KLC1, and TPR. Most of these ALK fus …
KIF5B-MET fusion variant in non-small cell lung cancer.
Costa E Silva M, Sucena I, Cirnes L, Machado JC, Campainha S, Barroso A. Costa E Silva M, et al. Pulmonology. 2022 Jul-Aug;28(4):315-316. doi: 10.1016/j.pulmoe.2022.02.001. Epub 2022 Feb 24. Pulmonology. 2022. PMID: 35221262 Free article. No abstract available.
Dominantly acting KIF5B variants with pleiotropic cellular consequences cause variable clinical phenotypes.
Flex E, Albadri S, Radio FC, Cecchetti S, Lauri A, Priolo M, Kissopoulos M, Carpentieri G, Fasano G, Venditti M, Magliocca V, Bellacchio E, Welch CL, Colombo PC, Kochav SM, Chang R, Barrick R, Trivisano M, Micalizzi A, Borghi R, Messina E, Mancini C, Pizzi S, De Santis F, Rosello M, Specchio N, Compagnucci C, McWalter K, Chung WK, Del Bene F, Tartaglia M. Flex E, et al. Hum Mol Genet. 2023 Jan 13;32(3):473-488. doi: 10.1093/hmg/ddac213. Hum Mol Genet. 2023. PMID: 36018820 Free PMC article.
Different from KIF5A and KIF5C, which are specifically expressed in neurons and established to cause neurological diseases when mutated, KIF5B is an ubiquitous protein. Three de novo missense KIF5B variants were recently described in four subjects with a syndromic s …
Different from KIF5A and KIF5C, which are specifically expressed in neurons and established to cause neurological diseases when mutated, …
Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling.
Marom R, Zhang B, Washington ME, Song IW, Burrage LC, Rossi VC, Berrier AS, Lindsey A, Lesinski J, Nonet ML, Chen J, Baldridge D, Silverman GA, Sutton VR, Rosenfeld JA, Tran AA, Hicks MJ, Murdock DR, Dai H, Weis M, Jhangiani SN, Muzny DM, Gibbs RA, Caswell R, Pottinger C, Cilliers D, Stals K; Undiagnosed Diseases Network; Eyre D, Krakow D, Schedl T, Pak SC, Lee BH. Marom R, et al. PLoS Genet. 2023 Nov 7;19(11):e1011005. doi: 10.1371/journal.pgen.1011005. eCollection 2023 Nov. PLoS Genet. 2023. PMID: 37934770 Free PMC article.
Pathogenic variants in kinesin-related genes have been implicated in neurodevelopmental disorders and skeletal dysplasias. We identified de novo, heterozygous variants in KIF5B, encoding a kinesin-1 subunit, in four individuals with osteogenesis imperfecta. ...This study e …
Pathogenic variants in kinesin-related genes have been implicated in neurodevelopmental disorders and skeletal dysplasias. We identified de …
KIF5B-mediated internalization of FMDV promotes virus infection.
Zhang W, Yang F, Yang Y, Cao W, Shao W, Wang J, Huang M, Chen Z, Zhao X, Li W, Zhu Z, Zheng H. Zhang W, et al. Virol Sin. 2024 Mar 16:S1995-820X(24)00031-2. doi: 10.1016/j.virs.2024.03.005. Online ahead of print. Virol Sin. 2024. PMID: 38499154 Free article.
In particular, the stalk [amino acids (aa) 413-678] domain of KIF5B was indispensable for KIF5B-VP1 interaction. Moreover, overexpression of KIF5B dramatically enhanced FMDV replication; consistently, knockdown or knockout of KIF5B suppressed FMDV repl …
In particular, the stalk [amino acids (aa) 413-678] domain of KIF5B was indispensable for KIF5B-VP1 interaction. Moreover, ove …
RET fusions in solid tumors.
Li AY, McCusker MG, Russo A, Scilla KA, Gittens A, Arensmeyer K, Mehra R, Adamo V, Rolfo C. Li AY, et al. Cancer Treat Rev. 2019 Dec;81:101911. doi: 10.1016/j.ctrv.2019.101911. Epub 2019 Oct 30. Cancer Treat Rev. 2019. PMID: 31715421 Review.
The most common RET fusions are CDCC6-RET and NCOA4-RET in PTC and KIF5B-RET in NSCLC. Tyrosine kinase inhibitors are drugs that target kinases such as RET in RET-driven (RET-mutation or RET-fusion-positive) disease. ...
The most common RET fusions are CDCC6-RET and NCOA4-RET in PTC and KIF5B-RET in NSCLC. Tyrosine kinase inhibitors are drugs that targ …
KIF5B plays important roles in dendritic spine plasticity and dendritic localization of PSD95 and FMRP in the mouse cortex in vivo.
Fok AHK, Huang Y, So BWL, Zheng Q, Tse CSC, Li X, Wong KK, Huang J, Lai KO, Lai CSW. Fok AHK, et al. Cell Rep. 2024 Mar 26;43(3):113906. doi: 10.1016/j.celrep.2024.113906. Epub 2024 Mar 7. Cell Rep. 2024. PMID: 38451812 Free article.
Using in vivo two-photon imaging, we find that conditional knockout of Kif5b (KIF5B cKO) in CaMKIIalpha-Cre-expressing neurons shows heightened turnover and lower stability of dendritic spines in layer 2/3 pyramidal neurons with reduced spine postsynaptic density pr …
Using in vivo two-photon imaging, we find that conditional knockout of Kif5b (KIF5B cKO) in CaMKIIalpha-Cre-expressing neurons …
miR-122-5p/KIF5B/AMPK/AKT regulatory network regulates the progression of NAFLD.
Zhang J, Huang H. Zhang J, et al. Am J Transl Res. 2021 Feb 15;13(2):696-707. eCollection 2021. Am J Transl Res. 2021. Retraction in: Am J Transl Res. 2021 Jun 15;13(6):7426.. PMID: 33594319 Free PMC article. Retracted.
The role of miR-122-5p on inflammatory factors (MCP-1, TNF-alpha, IL-10) and liver injury markers (AST, ALT) in vivo and in vitro was analyzed. RESULTS: miR-122-5p and KIF5B were both highly expressed in NAFLD patients' serum, rat liver tissue and primary hepatocytes, whil …
The role of miR-122-5p on inflammatory factors (MCP-1, TNF-alpha, IL-10) and liver injury markers (AST, ALT) in vivo and in vitro was analyz …
KIF5B-RET Oncoprotein Signals through a Multi-kinase Signaling Hub.
Das TK, Cagan RL. Das TK, et al. Cell Rep. 2017 Sep 5;20(10):2368-2383. doi: 10.1016/j.celrep.2017.08.037. Cell Rep. 2017. PMID: 28877471 Free PMC article.
The KIF5B-RET-transformed human bronchial cell line showed similar aspects of transformation, including invadopodia-like processes. ...We demonstrate that drugs designed to inhibit RET alone work poorly in KIF5B-RET-transformed cells. However, combining the RET inhi …
The KIF5B-RET-transformed human bronchial cell line showed similar aspects of transformation, including invadopodia-like processes. . …
539 results