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Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore BS, Lim SK, Yoon YJ. Mo S, et al. Among authors: kim e, kim dh, kim d, kim sj. J Am Chem Soc. 2011 Feb 2;133(4):976-85. doi: 10.1021/ja108399b. Epub 2010 Dec 22. J Am Chem Soc. 2011. PMID: 21175203 Free PMC article.
Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates.
Han AR, Park JW, Lee MK, Ban YH, Yoo YJ, Kim EJ, Kim E, Kim BG, Sohng JK, Yoon YJ. Han AR, et al. Among authors: kim e, kim ej, kim bg. Appl Environ Microbiol. 2011 Jul;77(14):4912-23. doi: 10.1128/AEM.02527-10. Epub 2011 May 20. Appl Environ Microbiol. 2011. PMID: 21602397 Free PMC article.
A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.
Jung WS, Yoo YJ, Park JW, Park SR, Han AR, Ban YH, Kim EJ, Kim E, Yoon YJ. Jung WS, et al. Among authors: kim e, kim ej. Appl Microbiol Biotechnol. 2011 Sep;91(5):1389-97. doi: 10.1007/s00253-011-3348-6. Epub 2011 Jun 8. Appl Microbiol Biotechnol. 2011. PMID: 21655985
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