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Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL.
Kim SM, Park HS, Jun DY, Woo HJ, Woo MH, Yang CH, Kim YH. Kim SM, et al. Among authors: kim yh. Toxicol Appl Pharmacol. 2009 Dec 1;241(2):210-20. doi: 10.1016/j.taap.2009.08.024. Epub 2009 Aug 28. Toxicol Appl Pharmacol. 2009. PMID: 19716835
Induction of microtubule-damage, mitotic arrest, Bcl-2 phosphorylation, Bak activation, and mitochondria-dependent caspase cascade is involved in human Jurkat T-cell apoptosis by aruncin B from Aruncus dioicus var. kamtschaticus.
Han CR, Jun do Y, Woo HJ, Jeong SY, Woo MH, Kim YH. Han CR, et al. Among authors: kim yh. Bioorg Med Chem Lett. 2012 Jan 15;22(2):945-53. doi: 10.1016/j.bmcl.2011.12.023. Epub 2011 Dec 9. Bioorg Med Chem Lett. 2012. PMID: 22197393
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