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Antiplatelet effect of NQ12: a possible mechanism through the arachidonic acid cascade.
Jin YR, Han XH, Lee JJ, Lim Y, Kim TJ, Yoo HS, Hong JT, Lee CK, Yun YP. Jin YR, et al. J Pharmacol Sci. 2007 Oct;105(2):193-200. doi: 10.1254/jphs.fp0071006. J Pharmacol Sci. 2007. PMID: 17951980 Free article.
NQ12 concentration-dependently suppressed collagen-, AA-, and U46619-induced rabbit platelet aggregation, with IC(50) values of 0.71 +/- 0.2, 0.82 +/- 0.3, and 0.45 +/- 0.1 microM, respectively. In addition, the concentration-response curve of U46619 was shifted to the rig …
NQ12 concentration-dependently suppressed collagen-, AA-, and U46619-induced rabbit platelet aggregation, with IC(50) values of 0.71 +/- 0.2 …