Klaassen CD - Search Results

1

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice.

Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, Guo GL. Kong B, et al. Among authors: klaassen cd. Hepatology. 2012 Sep;56(3):1034-43. doi: 10.1002/hep.25740. Epub 2012 Jul 12. Hepatology. 2012. PMID: 22467244 Free PMC article.

2

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.

Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD. Maher JM, et al. Among authors: klaassen cd. Hepatology. 2007 Nov;46(5):1597-610. doi: 10.1002/hep.21831. Hepatology. 2007. PMID: 17668877

3

Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice.

Zhang Y, Klaassen CD. Zhang Y, et al. Among authors: klaassen cd. J Lipid Res. 2010 Nov;51(11):3230-42. doi: 10.1194/jlr.M007641. Epub 2010 Jul 29. J Lipid Res. 2010. PMID: 20671298 Free PMC article.

4

Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.

Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD. Csanaky IL, et al. Among authors: klaassen cd. Hepatology. 2011 Jan;53(1):272-81. doi: 10.1002/hep.23984. Epub 2010 Oct 14. Hepatology. 2011. PMID: 20949553 Free PMC article.

5

Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters.

Zhang YK, Guo GL, Klaassen CD. Zhang YK, et al. Among authors: klaassen cd. PLoS One. 2011 Feb 8;6(2):e16683. doi: 10.1371/journal.pone.0016683. PLoS One. 2011. PMID: 21346810 Free PMC article.

6

Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.

Cui JY, Aleksunes LM, Tanaka Y, Fu ZD, Guo Y, Guo GL, Lu H, Zhong XB, Klaassen CD. Cui JY, et al. Among authors: klaassen cd. Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G979-96. doi: 10.1152/ajpgi.00370.2011. Epub 2012 Jan 19. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22268101 Free PMC article.

7

Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum.

Cheng X, Zhang Y, Klaassen CD. Cheng X, et al. Among authors: klaassen cd. J Pharmacol Exp Ther. 2014 Oct;351(1):105-13. doi: 10.1124/jpet.114.216796. Epub 2014 Jul 17. J Pharmacol Exp Ther. 2014. PMID: 25034404 Free PMC article.

8

Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.

Xiong H, Zhang C, Han L, Xu T, Saeed K, Han J, Liu J, Klaassen CD, Gonzalez FJ, Lu Y, Zhang Y. Xiong H, et al. Among authors: klaassen cd. Hepatology. 2022 Aug;76(2):387-403. doi: 10.1002/hep.32270. Epub 2022 Jan 22. Hepatology. 2022. PMID: 34870866

9

The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators.

Pacyniak EK, Cheng X, Cunningham ML, Crofton K, Klaassen CD, Guo GL. Pacyniak EK, et al. Among authors: klaassen cd. Toxicol Sci. 2007 May;97(1):94-102. doi: 10.1093/toxsci/kfm025. Epub 2007 Feb 25. Toxicol Sci. 2007. PMID: 17324954

10

Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice.

Song P, Zhang Y, Klaassen CD. Song P, et al. Among authors: klaassen cd. Toxicol Sci. 2011 Oct;123(2):359-67. doi: 10.1093/toxsci/kfr177. Epub 2011 Jul 11. Toxicol Sci. 2011. PMID: 21747115 Free PMC article.

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