Klabe RM - Search Results

1

Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.

Corbett JW, Ko SS, Rodgers JD, Gearhart LA, Magnus NA, Bacheler LT, Diamond S, Jeffrey S, Klabe RM, Cordova BC, Garber S, Logue K, Trainor GL, Anderson PS, Erickson-Viitanen SK. Corbett JW, et al. Among authors: klabe rm. J Med Chem. 2000 May 18;43(10):2019-30. doi: 10.1021/jm990580e. J Med Chem. 2000. PMID: 10821714

2

Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323.

Erickson-Viitanen S, Klabe RM, Cawood PG, O'Neal PL, Meek JL. Erickson-Viitanen S, et al. Among authors: klabe rm. Antimicrob Agents Chemother. 1994 Jul;38(7):1628-34. doi: 10.1128/AAC.38.7.1628. Antimicrob Agents Chemother. 1994. PMID: 7979296 Free PMC article.

3

Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.

Nugiel DA, Jacobs K, Kaltenbach RF, Worley T, Patel M, Meyer DT, Jadhav PK, De Lucca GV, Smyser TE, Klabe RM, Bacheler LT, Rayner MM, Seitz SP. Nugiel DA, et al. Among authors: klabe rm. J Med Chem. 1996 May 24;39(11):2156-69. doi: 10.1021/jm960083n. J Med Chem. 1996. PMID: 8667359

4

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al. Lam PY, et al. Among authors: klabe rm. J Med Chem. 1996 Aug 30;39(18):3514-25. doi: 10.1021/jm9602571. J Med Chem. 1996. PMID: 8784449

5

Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.

Ala PJ, Huston EE, Klabe RM, McCabe DD, Duke JL, Rizzo CJ, Korant BD, DeLoskey RJ, Lam PY, Hodge CN, Chang CH. Ala PJ, et al. Among authors: klabe rm. Biochemistry. 1997 Feb 18;36(7):1573-80. doi: 10.1021/bi962234u. Biochemistry. 1997. PMID: 9048541

6

Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.

Nugiel DA, Jacobs K, Cornelius L, Chang CH, Jadhav PK, Holler ER, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Logue KA, Gorey-Feret LJ, Lam GN, Erickson-Viitanen S, Seitz SP. Nugiel DA, et al. Among authors: klabe rm. J Med Chem. 1997 May 9;40(10):1465-74. doi: 10.1021/jm960839i. J Med Chem. 1997. PMID: 9154969

7

Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors.

De Lucca GV, Liang J, Aldrich PE, Calabrese J, Cordova B, Klabe RM, Rayner MM, Chang CH. De Lucca GV, et al. Among authors: klabe rm. J Med Chem. 1997 May 23;40(11):1707-9. doi: 10.1021/jm970081i. J Med Chem. 1997. PMID: 9171880

8

Resistance to HIV protease inhibitors: a comparison of enzyme inhibition and antiviral potency.

Klabe RM, Bacheler LT, Ala PJ, Erickson-Viitanen S, Meek JL. Klabe RM, et al. Biochemistry. 1998 Jun 16;37(24):8735-42. doi: 10.1021/bi972555l. Biochemistry. 1998. PMID: 9628735

9

Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.

De Lucca GV, Kim UT, Liang J, Cordova B, Klabe RM, Garber S, Bacheler LT, Lam GN, Wright MR, Logue KA, Erickson-Viitanen S, Ko SS, Trainor GL. De Lucca GV, et al. Among authors: klabe rm. J Med Chem. 1998 Jun 18;41(13):2411-23. doi: 10.1021/jm980103g. J Med Chem. 1998. PMID: 9632373

10

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.

Rodgers JD, Lam PY, Johnson BL, Wang H, Li R, Ru Y, Ko SS, Seitz SP, Trainor GL, Anderson PS, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Wright MR, Chang CH, Erickson-Viitanen S. Rodgers JD, et al. Among authors: klabe rm. Chem Biol. 1998 Oct;5(10):597-608. doi: 10.1016/s1074-5521(98)90117-x. Chem Biol. 1998. PMID: 9818151

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

44 results

Search Page