Kleinjans J - Search Results

1

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Ruiz-Aracama A, Peijnenburg A, Kleinjans J, Jennen D, van Delft J, Hellfrisch C, Lommen A. Ruiz-Aracama A, et al. Among authors: kleinjans j. BMC Genomics. 2011 May 20;12:251. doi: 10.1186/1471-2164-12-251. BMC Genomics. 2011. PMID: 21599895 Free PMC article.

2

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells.

Jennen D, Ruiz-Aracama A, Magkoufopoulou C, Peijnenburg A, Lommen A, van Delft J, Kleinjans J. Jennen D, et al. Among authors: kleinjans j. BMC Syst Biol. 2011 Aug 31;5:139. doi: 10.1186/1752-0509-5-139. BMC Syst Biol. 2011. PMID: 21880148 Free PMC article.

3

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro.

Van den Hof WF, Ruiz-Aracama A, Van Summeren A, Jennen DG, Gaj S, Coonen ML, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC. Van den Hof WF, et al. Among authors: kleinjans jc. Toxicol In Vitro. 2015 Apr;29(3):489-501. doi: 10.1016/j.tiv.2014.12.016. Epub 2015 Jan 3. Toxicol In Vitro. 2015. PMID: 25562108

4

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

Jetten MJ, Ruiz-Aracama A, Coonen ML, Claessen SM, van Herwijnen MH, Lommen A, van Delft JH, Peijnenburg AA, Kleinjans JC. Jetten MJ, et al. Among authors: kleinjans jc. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24. Arch Toxicol. 2016. PMID: 26104854 Free PMC article.

5

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH. Jennen DG, et al. Among authors: kleinjans jc. Toxicol Sci. 2010 May;115(1):66-79. doi: 10.1093/toxsci/kfq026. Epub 2010 Jan 27. Toxicol Sci. 2010. PMID: 20106945

6

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.

Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC. Jetten MJ, et al. Among authors: kleinjans jc. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi: 10.1016/j.taap.2012.01.009. Epub 2012 Jan 20. Toxicol Appl Pharmacol. 2012. PMID: 22285215 Clinical Trial.

7

Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo genotoxicity.

Tsamou M, Jennen DG, Claessen SM, Magkoufopoulou C, Kleinjans JC, van Delft JH. Tsamou M, et al. Among authors: kleinjans jc. Mutagenesis. 2012 Nov;27(6):645-52. doi: 10.1093/mutage/ges030. Epub 2012 Aug 21. Mutagenesis. 2012. PMID: 22914676

8

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells.

Magkoufopoulou C, Claessen SM, Jennen DG, Kleinjans JC, van Delft JH. Magkoufopoulou C, et al. Among authors: kleinjans jc. Mutagenesis. 2011 Sep;26(5):593-604. doi: 10.1093/mutage/ger021. Epub 2011 Jun 1. Mutagenesis. 2011. PMID: 21632981

9

Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.

Van Summeren A, Renes J, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC. Van Summeren A, et al. Among authors: kleinjans jc. Toxicol Sci. 2011 Mar;120(1):109-22. doi: 10.1093/toxsci/kfq380. Epub 2010 Dec 16. Toxicol Sci. 2011. PMID: 21163907

10

Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks.

Rieswijk L, Lizarraga D, Brauers KJ, Kleinjans JC, van Delft JH. Rieswijk L, et al. Among authors: kleinjans jc. Mutagenesis. 2014 Jan;29(1):17-26. doi: 10.1093/mutage/get055. Epub 2013 Nov 26. Mutagenesis. 2014. PMID: 24280081

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