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Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.
Zaharenko L, Kalnina I, Geldnere K, Konrade I, Grinberga S, Židzik J, Javorský M, Lejnieks A, Nikitina-Zake L, Fridmanis D, Peculis R, Radovica-Spalvina I, Hartmane D, Pugovics O, Tkáč I, Klimčáková L, Pīrāgs V, Klovins J. Zaharenko L, et al. Among authors: klimcakova l. Eur J Endocrinol. 2016 Dec;175(6):531-540. doi: 10.1530/EJE-16-0347. Epub 2016 Sep 8. Eur J Endocrinol. 2016. PMID: 27609360
A pharmacogenetic association between a variation in calpain 10 (CAPN10) gene and the response to metformin treatment in patients with type 2 diabetes.
Tkáč I, Javorský M, Klimčáková L, Židzik J, Gaľa I, Babjaková E, Schroner Z, Štolfová M, Hermanová H, Habalová V. Tkáč I, et al. Among authors: klimcakova l. Eur J Clin Pharmacol. 2015 Jan;71(1):59-63. doi: 10.1007/s00228-014-1774-y. Epub 2014 Oct 21. Eur J Clin Pharmacol. 2015. PMID: 25327507 Clinical Trial.
Variation in CDKAL1 gene is associated with therapeutic response to sulphonylureas.
Schroner Z, Javorský M, Halušková J, Klimčáková L, Babjaková E, Fabianová M, Slabá E, Kozárová M, Tkáč I. Schroner Z, et al. Among authors: klimcakova l. Physiol Res. 2012;61(2):177-83. doi: 10.33549/physiolres.932228. Epub 2012 Jan 31. Physiol Res. 2012. PMID: 22292718 Free article.
Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.
Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorský M, Goswami S, Zaharenko L, Hougaard Christensen MM, Out M, Tavendale R, Kubo M, Hedderson MM, van der Heijden AA, Klimčáková L, Pirags V, Kooy A, Brøsen K, Klovins J, Semiz S, Tkáč I, Stricker BH, Palmer C, 't Hart LM, Giacomini KM, Pearson ER. Dujic T, et al. Among authors: klimcakova l. Clin Pharmacol Ther. 2017 Jun;101(6):763-772. doi: 10.1002/cpt.567. Epub 2017 Feb 3. Clin Pharmacol Ther. 2017. PMID: 27859023 Free PMC article.
Variation in KCNQ1 is associated with therapeutic response to sulphonylureas.
Schroner Z, Dobrikova M, Klimcakova L, Javorsky M, Zidzik J, Kozarova M, Hudakova T, Tkacova R, Salagovic J, Tkac I. Schroner Z, et al. Among authors: klimcakova l. Med Sci Monit. 2011 Jul;17(7):CR392-6. doi: 10.12659/msm.881850. Med Sci Monit. 2011. PMID: 21709633 Free PMC article.
KCNJ11 gene E23K variant and therapeutic response to sulfonylureas.
Javorsky M, Klimcakova L, Schroner Z, Zidzik J, Babjakova E, Fabianova M, Kozarova M, Tkacova R, Salagovic J, Tkac I. Javorsky M, et al. Among authors: klimcakova l. Eur J Intern Med. 2012 Apr;23(3):245-9. doi: 10.1016/j.ejim.2011.10.018. Epub 2011 Nov 26. Eur J Intern Med. 2012. PMID: 22385882 Clinical Trial.
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