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1999 2
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2008 17
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300 results

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Page 1
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Chavarria-Smith J, Chiu CPC, Jackman JK, Yin J, Zhang J, Hackney JA, Lin WY, Tyagi T, Sun Y, Tao J, Dunlap D, Morton WD, Ghodge SV, Maun HR, Li H, Hernandez-Barry H, Loyet KM, Chen E, Liu J, Tam C, Yaspan BL, Cai H, Balazs M, Arron JR, Li J, Wittwer AJ, Pappu R, Austin CD, Lee WP, Lazarus RA, Sudhamsu J, Koerber JT, Yi T. Chavarria-Smith J, et al. Sci Transl Med. 2022 Dec 14;14(675):eabp9159. doi: 10.1126/scitranslmed.abp9159. Epub 2022 Dec 14. Sci Transl Med. 2022. PMID: 36516271
Here, we describe the discovery of inhibitory antibodies against murine KLK5 and KLK7 that could compensate for the deficiency of LEKTI in NS. ...To translate these findings, we engineered a humanized bispecific antibody capable of potent inhibition of human KLK5 an …
Here, we describe the discovery of inhibitory antibodies against murine KLK5 and KLK7 that could compensate for the deficiency of LEK …
KLK5, a novel potential suppressor of vaginal carcinogenesis.
Pampalakis G, Zingkou E, Sotiropoulou G. Pampalakis G, et al. Biol Chem. 2018 Sep 25;399(9):1107-1111. doi: 10.1515/hsz-2017-0302. Biol Chem. 2018. PMID: 29561728
Further, we propose that KLK5 could be implicated in vaginal cancer development based on the fact that Klk5-/- mice are prone to develop vaginal tumors when exposed to 7,12-dimethylbenz[a]anthracene. ...This explains the higher tumor numbers observed in Klk5- …
Further, we propose that KLK5 could be implicated in vaginal cancer development based on the fact that Klk5-/- mice are prone …
KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
Zhou S, Liu S, Tian G, Zhao L, Wang H, Li Y, Shen Y, Han L. Zhou S, et al. Gynecol Oncol. 2022 Jul;166(1):138-147. doi: 10.1016/j.ygyno.2022.05.010. Epub 2022 May 18. Gynecol Oncol. 2022. PMID: 35595569
OBJECTIVE: The role of kallikrein-related peptidase 5 (KLK5) has been studied in several diseases, including skin and ovarian cancers. ...However, downregulating KLK5 expression increased radiosensitivity. CONCLUSION: Our results confirm that KLK5 is vital to …
OBJECTIVE: The role of kallikrein-related peptidase 5 (KLK5) has been studied in several diseases, including skin and ovarian cancers …
KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome.
Furio L, Pampalakis G, Michael IP, Nagy A, Sotiropoulou G, Hovnanian A. Furio L, et al. PLoS Genet. 2015 Sep 21;11(9):e1005389. doi: 10.1371/journal.pgen.1005389. eCollection 2015 Sep. PLoS Genet. 2015. PMID: 26390218 Free PMC article.
However the contribution of these various proteases in the physiopathology remains to be determined. In this study, we developed a new murine model in which Klk5 and Spink5 were both knocked out to assess whether Klk5 deletion is sufficient to reverse the NS phenoty …
However the contribution of these various proteases in the physiopathology remains to be determined. In this study, we developed a new murin …
Cocktails of KLK5 Protease Inhibitors and Anti-TNFalpha Therapeutics: an Effective Treatment for Netherton Syndrome.
Zingkou E, Pampalakis G, Sotiropoulou G. Zingkou E, et al. J Clin Immunol. 2022 Apr;42(3):597-605. doi: 10.1007/s10875-021-01195-0. Epub 2022 Jan 18. J Clin Immunol. 2022. PMID: 35040012
Spink5(-/-) mice recapitulate major NS hallmarks and die homogeneously within 5 h from birth due to severe epidermal barrier defect leading to dehydration. Spink5(-/-)Klk5(-/-) mice survive neonatal lethality, indicating that KLK5 could be a drug target for NS. ...N …
Spink5(-/-) mice recapitulate major NS hallmarks and die homogeneously within 5 h from birth due to severe epidermal barrier defect leading …
KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes.
Nargis T, Kumar K, Ghosh AR, Sharma A, Rudra D, Sen D, Chakrabarti S, Mukhopadhyay S, Ganguly D, Chakrabarti P. Nargis T, et al. Mol Metab. 2017 Nov;6(11):1529-1539. doi: 10.1016/j.molmet.2017.09.004. Epub 2017 Sep 27. Mol Metab. 2017. PMID: 29107298 Free PMC article.
Expression and secretion of KLK5 is induced in CD4+ T cells of T2DM patients. In addition, KLK5 shed DPP4 from circulating CD4+ T helper (Th)17 cells and shed it into the plasma of T2DM patients. ...CONCLUSIONS: Our study provides mechanistic insights into the molec …
Expression and secretion of KLK5 is induced in CD4+ T cells of T2DM patients. In addition, KLK5 shed DPP4 from circulating CD4 …
Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma.
Alves MG, Kodama MH, da Silva EZM, Gomes BBM, da Silva RAA, Vieira GV, Alves VM, da Fonseca CK, Santana AC, Cecílio NT, Costa MSA, Jamur MC, Oliver C, Cunha TM, Bugge TH, Braz-Silva PH, Colli LM, Sales KU. Alves MG, et al. Transl Oncol. 2021 Jan;14(1):100970. doi: 10.1016/j.tranon.2020.100970. Epub 2020 Nov 28. Transl Oncol. 2021. PMID: 33260070 Free PMC article.
However, whether the activity of KLK5 promotes carcinogenesis is still controversial. Moreover, knowledge regarding the role of the KLK5 cognate inhibitor, Lympho-Epithelial Kazal-Type related Inhibitor (LEKTI), in OSCC is scarce. ...Indeed, disruption of KLK5 …
However, whether the activity of KLK5 promotes carcinogenesis is still controversial. Moreover, knowledge regarding the role of the …
KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R. Kasparek P, et al. PLoS Genet. 2017 Jan 17;13(1):e1006566. doi: 10.1371/journal.pgen.1006566. eCollection 2017 Jan. PLoS Genet. 2017. PMID: 28095415 Free PMC article.
We report that not only KLK5 but also KLK7 plays an important role in the inflammation and defective differentiation in NS and KLK7 activity is not solely dependent on activation by KLK5. Altogether, these findings show that unregulated activities of KLK5 and …
We report that not only KLK5 but also KLK7 plays an important role in the inflammation and defective differentiation in NS and KLK7 a …
Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.
Kang Y, Chen J, Li X, Luo M, Chen H, Cui B, Wang L, Lv D, Feng Y, Zhang P. Kang Y, et al. Cancer Biomark. 2021;31(4):317-328. doi: 10.3233/CBM-203105. Cancer Biomark. 2021. PMID: 33896830
KLK5 and uPA levels in saliva tended to increase as the disease progressed (healthy < OPMD [OLK and OLP] < OSCC). ...Their combined analysis showed a higher sensitivity for the differential diagnosis of disease. Furthermore, higher levels of KLK5 and uPA were …
KLK5 and uPA levels in saliva tended to increase as the disease progressed (healthy < OPMD [OLK and OLP] < OSCC). ...Their comb …
300 results