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1996 1
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318 results

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Page 1
KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages.
Hwang YS, Cho HJ, Park ES, Lim J, Yoon HR, Kim JT, Yoon SR, Jung H, Choe YK, Kim YH, Lee CH, Kwon YT, Kim BY, Lee HG. Hwang YS, et al. Cells. 2022 Dec 16;11(24):4101. doi: 10.3390/cells11244101. Cells. 2022. PMID: 36552865 Free PMC article.
However, the function of KLK6 in the tumor microenvironment remains unclear. This study aimed to determine the role of KLK6 in the tumor microenvironment. Here, we uncovered the mechanism underlying KLK6-mediated cross-talk between cancer cells and macrophage …
However, the function of KLK6 in the tumor microenvironment remains unclear. This study aimed to determine the role of KLK6 in …
KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma.
Zhao K, Gao M, Lin M. Zhao K, et al. Dis Markers. 2022 Sep 22;2022:3373851. doi: 10.1155/2022/3373851. eCollection 2022. Dis Markers. 2022. PMID: 36193495 Free PMC article.
Moreover, the TCGA database indicates that KLK6 high expression in BLCA patients showed a poorer prognosis than those patients with KLK6 low expression. ...KLK6 expression positively correlates with several immune cells infiltration, indicating that inhibitio …
Moreover, the TCGA database indicates that KLK6 high expression in BLCA patients showed a poorer prognosis than those patients with …
KLK6 mediates stemness and metabolism of gastric carcinoma cells via the PI3K/AKT/mTOR signaling pathway.
Zhou D, He Y, Li H, Huang W. Zhou D, et al. Oncol Lett. 2021 Dec;22(6):824. doi: 10.3892/ol.2021.13085. Epub 2021 Oct 12. Oncol Lett. 2021. PMID: 34691251 Free PMC article.
The HGC-27 cell line was transfected with KLK6 overexpression (OV-KLK6) and interference (short hairpin-KLK6) vectors, then the transfection efficiency was confirmed using western blot analysis and reverse transcription-quantitative PCR. ...Among them, sh-RNA …
The HGC-27 cell line was transfected with KLK6 overexpression (OV-KLK6) and interference (short hairpin-KLK6) vectors, …
KLK6 Promotes Growth, Migration, and Invasion of Gastric Cancer Cells.
Zhu S, Shi J, Zhang S, Li Z. Zhu S, et al. J Gastric Cancer. 2018 Dec;18(4):356-367. doi: 10.5230/jgc.2018.18.e35. Epub 2018 Nov 14. J Gastric Cancer. 2018. PMID: 30607299 Free PMC article.
Fluorescence-activated cell sorting was employed to sort 2 clones of SGC-7901 cells with distinct KLK6 expression, namely, KLK6-high (KLK6(high)) and KLK6-low (KLK6(low)), which were then expanded. ...Compared to KLK6(low) cells, KLK6 …
Fluorescence-activated cell sorting was employed to sort 2 clones of SGC-7901 cells with distinct KLK6 expression, namely, KLK6 …
KLK6 protease accelerates skin tumor formation and progression.
Khoury N, Zingkou E, Pampalakis G, Sofopoulos M, Zoumpourlis V, Sotiropoulou G. Khoury N, et al. Carcinogenesis. 2018 Dec 31;39(12):1529-1536. doi: 10.1093/carcin/bgy110. Carcinogenesis. 2018. PMID: 30137206
KLK6 is active in epidermis and has been linked to normal skin differentiation. ...Klk6-/- (but also Klk6+/-) mice were highly resistant to tumor growth/development manifested by their highly diminished numbers and delayed onset of tumors compared with wild-t …
KLK6 is active in epidermis and has been linked to normal skin differentiation. ...Klk6-/- (but also Klk6+/-) mice were …
KLK6-regulated miRNA networks activate oncogenic pathways in breast cancer subtypes.
Sidiropoulos KG, Ding Q, Pampalakis G, White NM, Boulos P, Sotiropoulou G, Yousef GM. Sidiropoulos KG, et al. Mol Oncol. 2016 Aug;10(7):993-1007. doi: 10.1016/j.molonc.2016.03.008. Epub 2016 Apr 8. Mol Oncol. 2016. PMID: 27093921 Free PMC article.
KLK6 is expressed in normal mammary tissues and is aberrantly regulated in breast cancer. ...Cancer Res 69:3779-3787, 2009). Here, we stably transfected KLK6-non-expressing MDA-MB-231 breast cancer cells with the full-length KLK6 cDNA to overexpress KLK6 …
KLK6 is expressed in normal mammary tissues and is aberrantly regulated in breast cancer. ...Cancer Res 69:3779-3787, 2009). Here, we …
Biochemical pathways mediated by KLK6 protease in breast cancer.
Pampalakis G, Zingkou E, Sidiropoulos KG, Diamandis EP, Zoumpourlis V, Yousef GM, Sotiropoulou G. Pampalakis G, et al. Mol Oncol. 2019 Nov;13(11):2329-2343. doi: 10.1002/1878-0261.12493. Epub 2019 Sep 30. Mol Oncol. 2019. PMID: 30980596 Free PMC article.
By integrating proteomics and microarray data from breast cancer patients, we generated two composite scores, KLK6 + S100B-S100A7 and KLK6 + S100B-S100A14-S100A16, to predict long-term survival of breast cancer patients. We present previously unknown pathways implic …
By integrating proteomics and microarray data from breast cancer patients, we generated two composite scores, KLK6 + S100B-S100A7 and …
Ectopic expression of KLK6 in MDA-MB-435 melanoma cells reduces tumorigenicity in vivo.
Pampalakis G, Zingkou E, Zoumpourlis V, Sotiropoulou G. Pampalakis G, et al. Pathol Res Pract. 2021 Jan;217:153276. doi: 10.1016/j.prp.2020.153276. Epub 2020 Nov 14. Pathol Res Pract. 2021. PMID: 33249398
To delineate putative roles of KLK6 in melanoma, the invasive KLK6-non-expressing MDA-MB-435 melanoma cell line was stably transfected with the full-length KLK6 cDNA and expression of the corresponding RNA and protein were confirmed. ...Analysis of data retri …
To delineate putative roles of KLK6 in melanoma, the invasive KLK6-non-expressing MDA-MB-435 melanoma cell line was stably tra …
KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruzska D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL. Billi AC, et al. J Clin Invest. 2020 Jun 1;130(6):3151-3157. doi: 10.1172/JCI133159. J Clin Invest. 2020. PMID: 32155135 Free PMC article.
Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease hypothesized to promote inflammation via cleavage of protease-activated receptor 1 (PAR1) and PAR2. KLK6 levels are elevated in multiple inflammatory and autoimmune conditions, but no definitive rol …
Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease hypothesized to promote inflammation via cleavage of protease-act …
KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species.
Pampalakis G, Sykioti VS, Ximerakis M, Stefanakou-Kalakou I, Melki R, Vekrellis K, Sotiropoulou G. Pampalakis G, et al. Oncotarget. 2017 Feb 28;8(9):14502-14515. doi: 10.18632/oncotarget.13264. Oncotarget. 2017. PMID: 27845893 Free PMC article.
KLK6 is a serine protease highly expressed in the nervous system. ...We generated adenoviral vectors for KLK6 delivery and demonstrated that the levels of extracellular alpha-synuclein can be reduced by neuronally secreted KLK6. ...
KLK6 is a serine protease highly expressed in the nervous system. ...We generated adenoviral vectors for KLK6 delivery and dem …
318 results