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Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.
Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS. Schietke RE, et al. Among authors: knaup kx. PLoS One. 2012;7(1):e31034. doi: 10.1371/journal.pone.0031034. Epub 2012 Jan 27. PLoS One. 2012. PMID: 22299048 Free PMC article.
The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.
Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup KX, Hackenbeck T, Bernhardt W, Willam C, Eckardt KU, Wiesener MS. Warnecke C, et al. Among authors: knaup kx. Exp Cell Res. 2008 Jun 10;314(10):2016-27. doi: 10.1016/j.yexcr.2008.03.003. Epub 2008 Mar 18. Exp Cell Res. 2008. PMID: 18420194
The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia.
Hackenbeck T, Huber R, Schietke R, Knaup KX, Monti J, Wu X, Klanke B, Frey B, Gaipl U, Wullich B, Ferbus D, Goubin G, Warnecke C, Eckardt KU, Wiesener MS. Hackenbeck T, et al. Among authors: knaup kx. Biochim Biophys Acta. 2011 Jan;1813(1):1-13. doi: 10.1016/j.bbamcr.2010.10.019. Epub 2010 Nov 5. Biochim Biophys Acta. 2011. PMID: 21056597 Free article.
31 results