Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

389 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.
Young WB, Mordenti J, Torkelson S, Shrader WD, Kolesnikov A, Rai R, Liu L, Hu H, Leahy EM, Green MJ, Sprengeler PA, Katz BA, Yu C, Janc JW, Elrod KC, Marzec UM, Hanson SR. Young WB, et al. Among authors: kolesnikov a. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2037-41. doi: 10.1016/j.bmcl.2005.12.059. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16412633
Development of potent and selective factor Xa inhibitors.
Rai R, Kolesnikov A, Li Y, Young WB, Leahy E, Sprengeler PA, Verner E, Shrader WD, Burgess-Henry J, Sangalang JC, Allen D, Chen X, Katz BA, Luong C, Elrod K, Cregar L. Rai R, et al. Among authors: kolesnikov a. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1797-800. doi: 10.1016/s0960-894x(01)00311-0. Bioorg Med Chem Lett. 2001. PMID: 11459634
Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.
Verner E, Katz BA, Spencer JR, Allen D, Hataye J, Hruzewicz W, Hui HC, Kolesnikov A, Li Y, Luong C, Martelli A, Radika K, Rai R, She M, Shrader W, Sprengeler PA, Trapp S, Wang J, Young WB, Mackman RL. Verner E, et al. Among authors: kolesnikov a. J Med Chem. 2001 Aug 16;44(17):2753-71. doi: 10.1021/jm0100638. J Med Chem. 2001. PMID: 11495587
Optimization of a screening lead for factor VIIa/TF.
Young WB, Kolesnikov A, Rai R, Sprengeler PA, Leahy EM, Shrader WD, Sangalang J, Burgess-Henry J, Spencer J, Elrod K, Cregar L. Young WB, et al. Among authors: kolesnikov a. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2253-6. doi: 10.1016/s0960-894x(01)00420-6. Bioorg Med Chem Lett. 2001. PMID: 11527709
Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation.
Young WB, Sprengeler P, Shrader WD, Li Y, Rai R, Verner E, Jenkins T, Fatheree P, Kolesnikov A, Janc JW, Cregar L, Elrod K, Katz B. Young WB, et al. Among authors: kolesnikov a. Bioorg Med Chem Lett. 2006 Feb;16(3):710-3. doi: 10.1016/j.bmcl.2005.10.023. Epub 2005 Oct 27. Bioorg Med Chem Lett. 2006. PMID: 16257204
Factor VIIa inhibitors: gaining selectivity within the trypsin family.
Shrader WD, Kolesnikov A, Burgess-Henry J, Rai R, Hendrix J, Hu H, Torkelson S, Ton T, Young WB, Katz BA, Yu C, Tang J, Cabuslay R, Sanford E, Janc JW, Sprengeler PA. Shrader WD, et al. Among authors: kolesnikov a. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1596-600. doi: 10.1016/j.bmcl.2005.12.040. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413783
Factor VIIa inhibitors: improved pharmacokinetic parameters.
Kolesnikov A, Rai R, Young WB, Mordenti J, Liu L, Torkelson S, Shrader WD, Leahy EM, Hu H, Gjerstad E, Janc J, Katz BA, Sprengeler PA. Kolesnikov A, et al. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2243-6. doi: 10.1016/j.bmcl.2006.01.037. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16455251
Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability.
Riggs JR, Kolesnikov A, Hendrix J, Young WB, Shrader WD, Vijaykumar D, Stephens R, Liu L, Pan L, Mordenti J, Green MJ, Sukbuntherng J. Riggs JR, et al. Among authors: kolesnikov a. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2224-8. doi: 10.1016/j.bmcl.2006.01.039. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458507
Discovery of novel heterocyclic factor VIIa inhibitors.
Rai R, Kolesnikov A, Sprengeler PA, Torkelson S, Ton T, Katz BA, Yu C, Hendrix J, Shrader WD, Stephens R, Cabuslay R, Sanford E, Young WB. Rai R, et al. Among authors: kolesnikov a. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2270-3. doi: 10.1016/j.bmcl.2006.01.017. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16460932
Novel 5-azaindole factor VIIa inhibitors.
Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB. Riggs JR, et al. Among authors: kolesnikov a. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3197-200. doi: 10.1016/j.bmcl.2006.03.049. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621549
389 results