Kopecky DJ - Search Results

1

Mukaiyama aldol-Prins cyclization cascade reaction: a formal total synthesis of leucascandrolide A.

Kopecky DJ, Rychnovsky SD. Kopecky DJ, et al. J Am Chem Soc. 2001 Aug 29;123(34):8420-1. doi: 10.1021/ja011377n. J Am Chem Soc. 2001. PMID: 11516301 No abstract available.

2

Improved procedure for the reductive acetylation of acyclic esters and a new synthesis of ethers.

Kopecky DJ, Rychnovsky SD. Kopecky DJ, et al. J Org Chem. 2000 Jan 14;65(1):191-8. doi: 10.1021/jo9914521. J Org Chem. 2000. PMID: 10813915

3

Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.

Guimarães CR, Kopecky DJ, Mihalic J, Shen S, Jeffries S, Thibault ST, Chen X, Walker N, Cardozo M. Guimarães CR, et al. Among authors: kopecky dj. J Am Chem Soc. 2009 Dec 23;131(50):18139-46. doi: 10.1021/ja9064359. J Am Chem Soc. 2009. PMID: 19924990

4

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.

Kopecky DJ, Hao X, Chen Y, Fu J, Jiao X, Jaen JC, Cardozo MG, Liu J, Wang Z, Walker NP, Wesche H, Li S, Farrelly E, Xiao SH, Kayser F. Kopecky DJ, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6352-6. doi: 10.1016/j.bmcl.2008.10.092. Epub 2008 Nov 1. Bioorg Med Chem Lett. 2008. PMID: 18993068

5

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

Chen X, Kopecky DJ, Mihalic J, Jeffries S, Min X, Heath J, Deignan J, Lai S, Fu Z, Guimaraes C, Shen S, Li S, Johnstone S, Thibault S, Xu H, Cardozo M, Shen W, Walker N, Kayser F, Wang Z. Chen X, et al. Among authors: kopecky dj. J Med Chem. 2012 Apr 26;55(8):3837-51. doi: 10.1021/jm300037x. Epub 2012 Apr 18. J Med Chem. 2012. PMID: 22458568

6

Discovery and optimization of a series of liver X receptor antagonists.

Jiao X, Kopecky DJ, Fisher B, Piper DE, Labelle M, McKendry S, Harrison M, Jones S, Jaen J, Shiau AK, Escaron P, Danao J, Chai A, Coward P, Kayser F. Jiao X, et al. Among authors: kopecky dj. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5966-70. doi: 10.1016/j.bmcl.2012.07.048. Epub 2012 Jul 21. Bioorg Med Chem Lett. 2012. PMID: 22901900

7

Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.

Jiao X, Kopecky DJ, Liu J, Liu J, Jaen JC, Cardozo MG, Sharma R, Walker N, Wesche H, Li S, Farrelly E, Xiao SH, Wang Z, Kayser F. Jiao X, et al. Among authors: kopecky dj. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6212-7. doi: 10.1016/j.bmcl.2012.08.020. Epub 2012 Aug 10. Bioorg Med Chem Lett. 2012. PMID: 22929232

8

Discovery of a new binding mode for a series of liver X receptor agonists.

Kopecky DJ, Jiao XY, Fisher B, McKendry S, Labelle M, Piper DE, Coward P, Shiau AK, Escaron P, Danao J, Chai A, Jaen J, Kayser F. Kopecky DJ, et al. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2407-10. doi: 10.1016/j.bmcl.2012.02.028. Epub 2012 Feb 20. Bioorg Med Chem Lett. 2012. PMID: 22406115

9

Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution.

Birkholz A, Kopecky DJ, Volak LP, Bartberger MD, Chen Y, Tegley CM, Arvedson T, McCarter JD, Fotsch C, Cee VJ. Birkholz A, et al. Among authors: kopecky dj. J Med Chem. 2020 Oct 22;63(20):11602-11614. doi: 10.1021/acs.jmedchem.0c00749. Epub 2020 Oct 9. J Med Chem. 2020. PMID: 32965113

10

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

Rew Y, Sun D, Gonzalez-Lopez De Turiso F, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Deignan J, Fox BM, Gustin D, Huang X, Jiang M, Jiao X, Jin L, Kayser F, Kopecky DJ, Li Y, Lo MC, Long AM, Michelsen K, Oliner JD, Osgood T, Ragains M, Saiki AY, Schneider S, Toteva M, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Medina JC, Olson SH. Rew Y, et al. Among authors: kopecky dj. J Med Chem. 2012 Jun 14;55(11):4936-54. doi: 10.1021/jm300354j. Epub 2012 May 9. J Med Chem. 2012. PMID: 22524527

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