Kostlan CR - Search Results

1

Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-one.

Sircar JC, Kostlan CR, Gilbertsen RB, Bennett MK, Dong MK, Cetenko WJ. Sircar JC, et al. Among authors: kostlan cr. J Med Chem. 1992 May 1;35(9):1605-9. doi: 10.1021/jm00087a015. J Med Chem. 1992. PMID: 1578487

2

Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.

Woo PW, Kostlan CR, Sircar JC, Dong MK, Gilbertsen RB. Woo PW, et al. Among authors: kostlan cr. J Med Chem. 1992 Apr 17;35(8):1451-7. doi: 10.1021/jm00086a014. J Med Chem. 1992. PMID: 1573639

3

Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor.

Gilbertsen RB, Dong MK, Wilburn DJ, Kossarek LM, Sircar JC, Kostlan CR, Conroy MC. Gilbertsen RB, et al. Among authors: kostlan cr. Adv Exp Med Biol. 1991;309A:41-4. doi: 10.1007/978-1-4899-2638-8_8. Adv Exp Med Biol. 1991. PMID: 1789255

4

Pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase (PNP) inhibitors as potential T-cell selective immunosuppressive agents.

Sircar JC, Kostlan CR, Gilbertsen RB, Dong MK, Cetenko WA. Sircar JC, et al. Among authors: kostlan cr. Adv Exp Med Biol. 1991;309A:45-8. doi: 10.1007/978-1-4899-2638-8_9. Adv Exp Med Biol. 1991. PMID: 1789265

5

Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.

Flynn DL, Belliotti TR, Boctor AM, Connor DT, Kostlan CR, Nies DE, Ortwine DF, Schrier DJ, Sircar JC. Flynn DL, et al. Among authors: kostlan cr. J Med Chem. 1991 Feb;34(2):518-25. doi: 10.1021/jm00106a006. J Med Chem. 1991. PMID: 1847426

6

Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972.

Gilbertsen RB, Dong MK, Kossarek LM, Sircar JC, Kostlan CR, Conroy MC. Gilbertsen RB, et al. Among authors: kostlan cr. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8. doi: 10.1016/0006-291x(91)91042-b. Biochem Biophys Res Commun. 1991. PMID: 1908235

7

Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.

Flynn DL, Capiris T, Cetenko WJ, Connor DT, Dyer RD, Kostlan CR, Nies DE, Schrier DJ, Sircar JC. Flynn DL, et al. Among authors: kostlan cr. J Med Chem. 1990 Aug;33(8):2070-2. doi: 10.1021/jm00170a004. J Med Chem. 1990. PMID: 2115586 No abstract available.

8

8-Amino-9-substituted guanines: potent purine nucleoside phosphorylase (PNP) inhibitors.

Sircar JC, Kostlan CR, Pinter GW, Suto MJ, Bobovski TP, Capiris T, Schwender CF, Dong MK, Scott ME, Bennett MK, et al. Sircar JC, et al. Among authors: kostlan cr. Agents Actions. 1987 Aug;21(3-4):253-6. doi: 10.1007/BF01966482. Agents Actions. 1987. PMID: 3120506

9

Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.

Unangst PC, Connor DT, Cetenko WA, Sorenson RJ, Kostlan CR, Sircar JC, Wright CD, Schrier DJ, Dyer RD. Unangst PC, et al. Among authors: kostlan cr. J Med Chem. 1994 Jan 21;37(2):322-8. doi: 10.1021/jm00028a017. J Med Chem. 1994. PMID: 8295221

10

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.

Boys ML, Bian F, Kramer JB, Chio CL, Ren XD, Chen H, Barrett SD, Sexton KE, Iula DM, Filzen GF, Nguyen MN, Angell P, Downs VL, Wang Z, Raheja N, Ellsworth EL, Fakhoury S, Bratton LD, Keller PR, Gowan R, Drummond EM, Maiti SN, Hena MA, Lu L, McConnell P, Knafels JD, Thanabal V, Sun F, Alessi D, McCarthy A, Zhang E, Finzel BC, Patel S, Ciotti SM, Eisma R, Payne NA, Gilbertsen RB, Kostlan CR, Pocalyko DJ, Lala DS. Boys ML, et al. Among authors: kostlan cr. Bioorg Med Chem Lett. 2012 May 15;22(10):3392-7. doi: 10.1016/j.bmcl.2012.04.013. Epub 2012 Apr 10. Bioorg Med Chem Lett. 2012. PMID: 22542194

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