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Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.
Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, Kouzarides T. Barbieri I, et al. Among authors: kouzarides t. Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27. Nature. 2017. PMID: 29186125 Free PMC article.
Reversing histone methylation.
Bannister AJ, Kouzarides T. Bannister AJ, et al. Among authors: kouzarides t. Nature. 2005 Aug 25;436(7054):1103-6. doi: 10.1038/nature04048. Nature. 2005. PMID: 16121170 Review.
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
Dawson MA, Bannister AJ, Göttgens B, Foster SD, Bartke T, Green AR, Kouzarides T. Dawson MA, et al. Among authors: kouzarides t. Nature. 2009 Oct 8;461(7265):819-22. doi: 10.1038/nature08448. Epub 2009 Sep 27. Nature. 2009. PMID: 19783980 Free PMC article.
RNA-modifying enzymes and their function in a chromatin context.
Tzelepis K, Rausch O, Kouzarides T. Tzelepis K, et al. Among authors: kouzarides t. Nat Struct Mol Biol. 2019 Oct;26(10):858-862. doi: 10.1038/s41594-019-0312-0. Epub 2019 Oct 3. Nat Struct Mol Biol. 2019. PMID: 31582848 Free PMC article. Review.
Role of RNA modifications in cancer.
Barbieri I, Kouzarides T. Barbieri I, et al. Among authors: kouzarides t. Nat Rev Cancer. 2020 Jun;20(6):303-322. doi: 10.1038/s41568-020-0253-2. Epub 2020 Apr 16. Nat Rev Cancer. 2020. PMID: 32300195 Review.
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, Webster NA, Andrews B, Fosbeary R, Guest P, Irigoyen N, Eleftheriou M, Gozdecka M, Dias JML, Bannister AJ, Vick B, Jeremias I, Vassiliou GS, Rausch O, Tzelepis K, Kouzarides T. Yankova E, et al. Among authors: kouzarides t. Nature. 2021 May;593(7860):597-601. doi: 10.1038/s41586-021-03536-w. Epub 2021 Apr 26. Nature. 2021. PMID: 33902106 Free PMC article.
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS. Tzelepis K, et al. Among authors: kouzarides t. Nat Commun. 2018 Dec 19;9(1):5378. doi: 10.1038/s41467-018-07620-0. Nat Commun. 2018. PMID: 30568163 Free PMC article.
Histone methylation: dynamic or static?
Bannister AJ, Schneider R, Kouzarides T. Bannister AJ, et al. Among authors: kouzarides t. Cell. 2002 Jun 28;109(7):801-6. doi: 10.1016/s0092-8674(02)00798-5. Cell. 2002. PMID: 12110177 Free article. Review.
Active genes are tri-methylated at K4 of histone H3.
Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, Emre NC, Schreiber SL, Mellor J, Kouzarides T. Santos-Rosa H, et al. Among authors: kouzarides t. Nature. 2002 Sep 26;419(6905):407-11. doi: 10.1038/nature01080. Epub 2002 Sep 11. Nature. 2002. PMID: 12353038
200 results