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Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.
Gao Z, Rasmussen TP, Li Y, Kutschke W, Koval OM, Wu Y, Wu Y, Hall DD, Joiner ML, Wu XQ, Swaminathan PD, Purohit A, Zimmerman K, Weiss RM, Philipson KD, Song LS, Hund TJ, Anderson ME. Gao Z, et al. Among authors: koval om. Circ Res. 2013 Jan 18;112(2):309-17. doi: 10.1161/CIRCRESAHA.111.300193. Epub 2012 Nov 27. Circ Res. 2013. PMID: 23192947 Free PMC article.
Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease.
Le Scouarnec S, Bhasin N, Vieyres C, Hund TJ, Cunha SR, Koval O, Marionneau C, Chen B, Wu Y, Demolombe S, Song LS, Le Marec H, Probst V, Schott JJ, Anderson ME, Mohler PJ. Le Scouarnec S, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15617-22. doi: 10.1073/pnas.0805500105. Epub 2008 Oct 1. Proc Natl Acad Sci U S A. 2008. PMID: 18832177 Free PMC article.
Proarrhythmic defects in Timothy syndrome require calmodulin kinase II.
Thiel WH, Chen B, Hund TJ, Koval OM, Purohit A, Song LS, Mohler PJ, Anderson ME. Thiel WH, et al. Among authors: koval om. Circulation. 2008 Nov 25;118(22):2225-34. doi: 10.1161/CIRCULATIONAHA.108.788067. Epub 2008 Nov 10. Circulation. 2008. PMID: 19001023 Free PMC article.
Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Wu Y, et al. Among authors: koval om. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5972-7. doi: 10.1073/pnas.0806422106. Epub 2009 Mar 10. Proc Natl Acad Sci U S A. 2009. PMID: 19276108 Free PMC article.
EH domain proteins regulate cardiac membrane protein targeting.
Gudmundsson H, Hund TJ, Wright PJ, Kline CF, Snyder JS, Qian L, Koval OM, Cunha SR, George M, Rainey MA, Kashef FE, Dun W, Boyden PA, Anderson ME, Band H, Mohler PJ. Gudmundsson H, et al. Among authors: koval om. Circ Res. 2010 Jul 9;107(1):84-95. doi: 10.1161/CIRCRESAHA.110.216713. Epub 2010 May 20. Circ Res. 2010. PMID: 20489164 Free PMC article.
52 results