Kraker A - Search Results

1

Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.

Smaill JB, Lee HH, Palmer BD, Thompson AM, Squire CJ, Baker EN, Booth RJ, Kraker A, Hook K, Denny WA. Smaill JB, et al. Among authors: kraker a. Bioorg Med Chem Lett. 2008 Feb 1;18(3):929-33. doi: 10.1016/j.bmcl.2007.12.046. Epub 2008 Jan 11. Bioorg Med Chem Lett. 2008. PMID: 18191399

2

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.

Palmer BD, Thompson AM, Booth RJ, Dobrusin EM, Kraker AJ, Lee HH, Lunney EA, Mitchell LH, Ortwine DF, Smaill JB, Swan LM, Denny WA. Palmer BD, et al. Among authors: kraker aj. J Med Chem. 2006 Aug 10;49(16):4896-911. doi: 10.1021/jm0512591. J Med Chem. 2006. PMID: 16884302

3

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.

Smaill JB, Baker EN, Booth RJ, Bridges AJ, Dickson JM, Dobrusin EM, Ivanovic I, Kraker AJ, Lee HH, Lunney EA, Ortwine DF, Palmer BD, Quin J 3rd, Squire CJ, Thompson AM, Denny WA. Smaill JB, et al. Among authors: kraker aj. Eur J Med Chem. 2008 Jun;43(6):1276-96. doi: 10.1016/j.ejmech.2007.07.016. Epub 2007 Aug 6. Eur J Med Chem. 2008. PMID: 17869387

4

Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1.

Palmer BD, Smaill JB, Rewcastle GW, Dobrusin EM, Kraker A, Moore CW, Steinkampf RW, Denny WA. Palmer BD, et al. Among authors: kraker a. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1931-5. doi: 10.1016/j.bmcl.2005.01.079. Bioorg Med Chem Lett. 2005. PMID: 15780636

5

Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases.

Palmer BD, Rewcastle GW, Thompson AM, Boyd M, Showalter HD, Sercel AD, Fry DW, Kraker AJ, Denny WA. Palmer BD, et al. Among authors: kraker aj. J Med Chem. 1995 Jan 6;38(1):58-67. doi: 10.1021/jm00001a011. J Med Chem. 1995. PMID: 7837241

6

Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide).

Rewcastle GW, Palmer BD, Dobrusin EM, Fry DW, Kraker AJ, Denny WA. Rewcastle GW, et al. Among authors: kraker aj. J Med Chem. 1994 Jun 24;37(13):2033-42. doi: 10.1021/jm00039a016. J Med Chem. 1994. PMID: 8027985

7

Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids).

Thompson AM, Rewcastle GW, Tercel M, Dobrusin EM, Fry DW, Kraker AJ, Denny WA. Thompson AM, et al. Among authors: kraker aj. J Med Chem. 1993 Aug 20;36(17):2459-69. doi: 10.1021/jm00069a003. J Med Chem. 1993. PMID: 8355247

8

Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

Rewcastle GW, Palmer BD, Bridges AJ, Showalter HD, Sun L, Nelson J, McMichael A, Kraker AJ, Fry DW, Denny WA. Rewcastle GW, et al. Among authors: kraker aj. J Med Chem. 1996 Feb 16;39(4):918-28. doi: 10.1021/jm950692f. J Med Chem. 1996. PMID: 8632415

9

Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor.

Palmer BD, Smaill JB, Boyd M, Boschelli DH, Doherty AM, Hamby JM, Khatana SS, Kramer JB, Kraker AJ, Panek RL, Lu GH, Dahring TK, Winters RT, Showalter HD, Denny WA. Palmer BD, et al. Among authors: kraker aj. J Med Chem. 1998 Dec 31;41(27):5457-65. doi: 10.1021/jm9804681. J Med Chem. 1998. PMID: 9876115

10

Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor.

Palmer BD, Kraker AJ, Hartl BG, Panopoulos AD, Panek RL, Batley BL, Lu GH, Trumpp-Kallmeyer S, Showalter HD, Denny WA. Palmer BD, et al. Among authors: kraker aj. J Med Chem. 1999 Jul 1;42(13):2373-82. doi: 10.1021/jm980658b. J Med Chem. 1999. PMID: 10395478

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