Krall J - Search Results

1

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs.

Krall J, Jensen CH, Bavo F, Falk-Petersen CB, Haugaard AS, Vogensen SB, Tian Y, Nittegaard-Nielsen M, Sigurdardóttir SB, Kehler J, Kongstad KT, Gloriam DE, Clausen RP, Harpsøe K, Wellendorph P, Frølund B. Krall J, et al. J Med Chem. 2017 Nov 9;60(21):9022-9039. doi: 10.1021/acs.jmedchem.7b01351. Epub 2017 Oct 30. J Med Chem. 2017. PMID: 29028338

2

Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships.

Møller HA, Sander T, Kristensen JL, Nielsen B, Krall J, Bergmann ML, Christiansen B, Balle T, Jensen AA, Frølund B. Møller HA, et al. Among authors: krall j. J Med Chem. 2010 Apr 22;53(8):3417-21. doi: 10.1021/jm100106r. J Med Chem. 2010. PMID: 20355712

3

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.

Jensen AA, Plath N, Pedersen MH, Isberg V, Krall J, Wellendorph P, Stensbøl TB, Gloriam DE, Krogsgaard-Larsen P, Frølund B. Jensen AA, et al. Among authors: krall j. J Med Chem. 2013 Feb 14;56(3):1211-27. doi: 10.1021/jm301656h. Epub 2013 Jan 17. J Med Chem. 2013. PMID: 23301527

4

Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation.

Krall J, Jensen CH, Sørensen TE, Nielsen B, Jensen AA, Sander T, Balle T, Frølund B. Krall J, et al. J Med Chem. 2013 Aug 22;56(16):6536-40. doi: 10.1021/jm4006466. Epub 2013 Aug 8. J Med Chem. 2013. PMID: 23855889

5

5-(Piperidin-4-yl)-3-hydroxypyrazole: A novel scaffold for probing the orthosteric γ-aminobutyric acid type A receptor binding site.

Krall J, Kongstad KT, Nielsen B, Sørensen TE, Balle T, Jensen AA, Frølund B. Krall J, et al. ChemMedChem. 2014 Nov;9(11):2475-85. doi: 10.1002/cmdc.201402248. Epub 2014 Aug 26. ChemMedChem. 2014. PMID: 25156407

6

Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain.

Hoestgaard-Jensen K, Dalby NO, Krall J, Hammer H, Krogsgaard-Larsen P, Frølund B, Jensen AA. Hoestgaard-Jensen K, et al. Among authors: krall j. J Neurosci. 2014 Dec 3;34(49):16256-72. doi: 10.1523/JNEUROSCI.1495-14.2014. J Neurosci. 2014. PMID: 25471566 Free PMC article.

7

GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology.

Krall J, Balle T, Krogsgaard-Larsen N, Sørensen TE, Krogsgaard-Larsen P, Kristiansen U, Frølund B. Krall J, et al. Adv Pharmacol. 2015;72:201-27. doi: 10.1016/bs.apha.2014.10.003. Epub 2014 Dec 4. Adv Pharmacol. 2015. PMID: 25600372 Review.

8

Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ₁ γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone.

Krall J, Brygger BM, Sigurðardóttir SB, Ng CK, Bundgaard C, Kehler J, Nielsen B, Bek T, Jensen AA, Frølund B. Krall J, et al. ChemMedChem. 2016 Oct 19;11(20):2299-2310. doi: 10.1002/cmdc.201600356. Epub 2016 Sep 13. ChemMedChem. 2016. PMID: 27620323

9

Imidazole-4-acetic acid, a new lead structure for interaction with the taurine transporter in outer blood-retinal barrier cells.

Valembois S, Krall J, Frølund B, Steffansen B. Valembois S, et al. Among authors: krall j. Eur J Pharm Sci. 2017 May 30;103:77-84. doi: 10.1016/j.ejps.2017.02.041. Epub 2017 Mar 1. Eur J Pharm Sci. 2017. PMID: 28259832

10

4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site.

Giraudo A, Krall J, Nielsen B, Sørensen TE, Kongstad KT, Rolando B, Boschi D, Frølund B, Lolli ML. Giraudo A, et al. Among authors: krall j. Eur J Med Chem. 2018 Oct 5;158:311-321. doi: 10.1016/j.ejmech.2018.08.094. Epub 2018 Sep 5. Eur J Med Chem. 2018. PMID: 30223119 Free article.

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