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KRCC1, a modulator of the DNA damage response.
Neizer-Ashun F, Dwivedi SKD, Dey A, Thavathiru E, Berry WL, Lees-Miller SP, Mukherjee P, Bhattacharya R. Neizer-Ashun F, et al. Nucleic Acids Res. 2022 Oct 28;50(19):11028-11039. doi: 10.1093/nar/gkac890. Nucleic Acids Res. 2022. PMID: 36243983 Free PMC article.
Despite a potential role in cancer progression, the biology of KRCC1 remains elusive. Here, we characterize the biology of KRCC1 and define its role in the DNA damage response and in cell cycle progression. ...Furthermore, KRCC1 is required for proper S-phase …
Despite a potential role in cancer progression, the biology of KRCC1 remains elusive. Here, we characterize the biology of KRCC1
KRCC1: A potential therapeutic target in ovarian cancer.
Dwivedi SKD, Shameer K, Dey A, Mustafi SB, Xiong X, Bhattacharya U, Neizer-Ashun F, Rao G, Wang Y, Ivan C, Yang D, Dudley JT, Xu C, Wren JD, Mukherjee P, Bhattacharya R. Dwivedi SKD, et al. FASEB J. 2020 Feb;34(2):2287-2300. doi: 10.1096/fj.201902259R. Epub 2019 Dec 23. FASEB J. 2020. PMID: 31908025 Free PMC article.
Using a systems biology approach to prioritize potential points of intervention in ovarian cancer, we identified the lysine rich coiled-coil 1 (KRCC1), as a potential target. High-grade serous ovarian cancer patient tumors and cells express significantly higher levels of …
Using a systems biology approach to prioritize potential points of intervention in ovarian cancer, we identified the lysine rich coiled-coil …
Increased expression of MERTK is associated with a unique form of canine retinopathy.
Ahonen SJ, Arumilli M, Seppälä E, Hakosalo O, Kaukonen MK, Komáromy AM, Lohi H. Ahonen SJ, et al. PLoS One. 2014 Dec 17;9(12):e114552. doi: 10.1371/journal.pone.0114552. eCollection 2014. PLoS One. 2014. PMID: 25517981 Free PMC article.
The expression analyses of four candidate genes in the region, MERTK, NPHP1, ANAPC1 and KRCC1, revealed specific upregulation of MERTK in the retina of the affected dogs. ...
The expression analyses of four candidate genes in the region, MERTK, NPHP1, ANAPC1 and KRCC1, revealed specific upregulation of MERT …